Furuoka H, Amanai H, Taniyama H, Matsui T
Department of Veterinary Pathology, Obihiro University of Agriculture and Veterinary Medicine, Japan.
J Comp Pathol. 1992 Aug;107(2):169-77. doi: 10.1016/0021-9975(92)90033-q.
Three aged (10-year-old) German Shepherd Dog litter mates, separately reared, were affected with familial and adult onset peripheral neuropathy. They developed clinical signs, unsteady gait of their hind legs with progressive muscular weakness at almost the same time. The main lesions were systemic neurogenic muscular atrophy, segmental demyelination and Wallerian degeneration of the peripheral nerve fibres. Histochemically, collateral ramification and multiple terminal arborization were observed in terminal axons of motor neurones in the muscles. These changes were attributed to a dying-back process.
三只（10岁）德国牧羊犬同窝幼犬，分别饲养，患有家族性和成年期外周神经病变。它们几乎同时出现临床症状，后腿步态不稳且伴有进行性肌肉无力。主要病变为全身性神经源性肌肉萎缩、外周神经纤维节段性脱髓鞘和华勒氏变性。组织化学检查发现，肌肉中运动神经元的终末轴突出现侧支分支和多个终末分支。这些变化归因于逆行性变性过程。
