Caballero Miguel, Bernal-Sprekelsen Manuel, Calvo Carlos, Farrè Xavier, Quintó Lorenc, Alòs Lucia
Department of Otorhinolaryngology, Hospital Clínic of Barcelona, Spain.
J Biomed Mater Res B Appl Biomater. 2003 Oct 15;67(1):666-74. doi: 10.1002/jbm.b.10061.
The objective is to study the tissue reaction of the paralyzed vocal cord in response to the injection of particulate plastics in a rabbit model. Forty-five New Zealand rabbits with surgical vocal-fold paralysis were used in the study. Histologic reactions of the larynx and the regional lymph nodes were analyzed by a single blinded pathologist at 6 weeks and 6 months after a vocal-cord injection of Teflon or of silicone elastomer. Macroscopic studies of the liver, lungs, spleen, kidney, and brain were performed. The histological study showed a greater proportion of chronic granulomatous inflammation in animals injected with silicone than in those injected with Teflon. The immunohistochemical study showed a higher degree of phagocytosis of Teflon particles than of the silicone particles. The silicone group presented a more severe fibrous reaction than the Teflon group, but the difference was not significant. No migration particles were found. It is concluded that silicone, having a greater viscosity than Teflon because of the size of its particles, induces more fibrosis and a larger proportion of foreign giant cells in the host. Due to this histological reaction, silicone particles present greater anchorage and stability.
目的是在兔模型中研究麻痹声带对注射颗粒状塑料的组织反应。该研究使用了45只接受手术导致声带麻痹的新西兰兔。在声带注射聚四氟乙烯或硅酮弹性体后6周和6个月，由一名单盲病理学家分析喉部和局部淋巴结的组织学反应。对肝脏、肺、脾、肾和脑进行了宏观研究。组织学研究表明，注射硅酮的动物中慢性肉芽肿性炎症的比例高于注射聚四氟乙烯的动物。免疫组织化学研究表明，聚四氟乙烯颗粒的吞噬程度高于硅酮颗粒。硅酮组的纤维反应比聚四氟乙烯组更严重，但差异不显著。未发现迁移颗粒。结论是，由于颗粒大小，硅酮的粘度比聚四氟乙烯大，在宿主体内诱导更多纤维化和更大比例的异物巨细胞。由于这种组织学反应，硅酮颗粒具有更大的锚定作用和稳定性。
