Cashman Steve, Simpson C Blake, McGuff H Stan
Department of Otolaryngology-Head and Neck Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284-7777, USA.
Ann Otol Rhinol Laryngol. 2002 Nov;111(11):977-82. doi: 10.1177/000348940211101105.
The use of Gore-Tex (expanded polytetrafluoroethylene) for medialization laryngoplasty has recently been described. Clinically, this laryngeal implant has performed well, but no animal studies evaluating the use of this implant in the larynx have been published. This study examines the gross and histologic response of the rabbit larynx to the Gore-Tex implant. Five rabbits underwent bilateral medialization with the Gore Thyroplasty Device. The vocal folds were left innervated and mobile. After 6 months, the rabbits were painlessly sacrificed and the implants were evaluated by gross inspection and histologic examination. No gross changes to the glottis occurred, and the implants were easily removed with gentle traction. A modest inflammatory response with a thin fibrous capsule was present around the implant. Foreign body giant cells were observed at the interface of the implant with the tissue. No migration or extrusion of the implant was observed. These results suggest that Gore-Tex is biocompatible in the rabbit larynx.
最近有文献报道了使用戈尔特斯（膨体聚四氟乙烯）进行喉内移术。临床上，这种喉植入物表现良好，但尚未发表评估该植入物在喉部应用的动物研究。本研究考察了兔喉对戈尔特斯植入物的大体及组织学反应。五只兔子接受了使用戈尔甲状腺成形装置的双侧喉内移术。保留声带的神经支配和活动度。6个月后，对兔子实施无痛安乐死，并通过大体检查和组织学检查对植入物进行评估。声门未出现明显变化，轻轻牵拉即可轻松取出植入物。植入物周围有适度的炎症反应，并伴有薄纤维包膜。在植入物与组织的界面处观察到异物巨细胞。未观察到植入物的迁移或挤出。这些结果表明，戈尔特斯在兔喉中具有生物相容性。
