Witte Torsten, Matthias Torsten, Oppermann Martina, Helmke Klaus, Peter Hans H, Schmidt Reinhold E, Tishler Moshe
Abteilung Klinische Immunologie, Medizinische Hochschule, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.
J Rheumatol. 2003 Oct;30(10):2157-9.
To compare the prevalence of antibodies against alpha-fodrin in Sjögren's syndrome (SS) classified according to San Diego and European Community Study Group (ESG) criteria.
The prevalence and mean concentrations of IgA and IgG autoantibodies against alpha-fodrin were determined and compared in patients with SS classified either according to San Diego criteria or to criteria of the ESG by ELISA.
IgA antibodies against alpha-fodrin were detected in 88% and IgG antibodies against alpha-fodrin in 64% and either of these antibodies in 93% of 85 patients classified according to San Diego criteria. Antibodies against Ro were present in 38% of these sera. IgA antibodies against alpha-fodrin were detected in 61%, IgG antibodies against alpha-fodrin in 51%, and any of these antibodies in 73% of 51 patients classified according to the ESG criteria. The mean concentrations of both IgA and IgG antibodies against alpha-fodrin that seem to correlate with disease activity were higher in patients classified according to the San Diego criteria.
Antibodies against alpha-fodrin are detectable in almost all sera obtained from patients with SS classified according to the San Diego criteria and are significantly more prevalent than antibodies against Ro. The lower prevalence of the autoantibodies in patients classified according to the ESG criteria reflects the lower specificity of these criteria for SS.
比较根据圣地亚哥标准和欧洲共同体研究组（ESG）标准分类的干燥综合征（SS）患者中抗α- fodrin抗体的患病率。
通过酶联免疫吸附测定法（ELISA）测定并比较根据圣地亚哥标准或ESG标准分类的SS患者中抗α- fodrin的IgA和IgG自身抗体的患病率及平均浓度。
在根据圣地亚哥标准分类的85例患者中，88%检测到抗α- fodrin的IgA抗体，64%检测到抗α- fodrin的IgG抗体，93%检测到其中任何一种抗体。这些血清中38%存在抗Ro抗体。在根据ESG标准分类的51例患者中，61%检测到抗α- fodrin的IgA抗体，51%检测到抗α- fodrin的IgG抗体，73%检测到其中任何一种抗体。根据圣地亚哥标准分类的患者中，似乎与疾病活动相关的抗α- fodrin的IgA和IgG抗体的平均浓度更高。
在根据圣地亚哥标准分类的SS患者获得的几乎所有血清中都可检测到抗α- fodrin抗体，且其患病率明显高于抗Ro抗体。根据ESG标准分类的患者中自身抗体患病率较低，反映了这些标准对SS的特异性较低。
