Yamada Akitoshi, Takeda Yoshitaka, Hayashi Satoru, Shimizu Kazuta
Department of Surgery, Suma Red Cross Hospital, Kobe, Hyogo, Japan.
Jpn J Thorac Cardiovasc Surg. 2003 Sep;51(9):456-8. doi: 10.1007/BF02719603.
We experienced a case of familial spontaneous pneumothorax in three generations. Six of 13 family members had episodes of spontaneous pneumothorax. It is well established that there are some diseases associated with human leukocyte antigen (HLA). We performed HLA phenotyping for HLA of A, B and C. In our study, we detected the HLA haplotype A2, B61 in three of 4 who had episodes of spontaneous pneumothorax. The HLA haplotype A2, B70 were also detected in three of 4 who had episodes. This suggests that familial spontaneous pneumothorax might have hereditary factors.
