Wilson W G, Aylsworth A S
Pediatrics. 1979 Aug;64(2):172-5.
A family is described in which four persons in three generations suffered spontaneous pneumothoraces: a newborn, an infant, an adolescent, and an adult. Review of the literature reveals 61 reports of familial spontaneous pneumothorax in 22 families. The ratio of male to female cases is approximately 1.8. Affected parents and affected children (including affected fathers and sons) are seen in ten families, while affected siblings with unaffected parents are noted in 13 families. Consanguinity has not been reported. Although autosomal dominant inheritance has been suggested as an explanation of familial spontaneous pneumothorax, available pedigree data are not adequate for statistical analysis. Physicians should be aware of the familial occurrence of spontaneous pneumothorax so that members of such families may be appropriately managed when problems arise.
本文描述了一个家族，该家族三代人中的四人患有自发性气胸，分别是一名新生儿、一名婴儿、一名青少年和一名成年人。文献回顾显示，在22个家族中有61例家族性自发性气胸的报告。男性病例与女性病例的比例约为1.8。在10个家族中观察到受影响的父母和受影响的子女（包括受影响的父子），而在13个家族中注意到父母未受影响的受影响兄弟姐妹。尚未有近亲结婚的报告。虽然常染色体显性遗传被认为是家族性自发性气胸的一种解释，但现有的系谱数据不足以进行统计分析。医生应该意识到自发性气胸的家族性发生，以便在出现问题时对这类家族的成员进行适当的处理。
