Loubatières-Mariani M M, Chapal J, Valette G
C R Seances Soc Biol Fil. 1977;171(4):864-9.
In the presence of a glucose concentration of 1.5 g/1, ATP provokes a biphasic stimulation of insulin secretion from the isolated and perfused rat pancreas. For ATP concentrations ranging from 0.5 mg/1 to 200 mg/1, the increase in insulin secretion presents a linear relation with the logarithm of the concentration. Lowering the temperature from 37.5 degrees C to 28 degrees C provokes a decrease in insulin secretion induced by glucose (1.5 g/1). In response to the stimulation by ATP, the increase in insulin secretion measured during the first phase is weaker at 28 degrees C than at 37.5 degrees C when estimated in ng/min; however, when evaluated in percentage in relation to the baseline value, this increase is more important at the lower temperature.
在葡萄糖浓度为1.5 g/1的情况下，ATP对离体灌注大鼠胰腺的胰岛素分泌有双相刺激作用。对于浓度范围在0.5 mg/1至200 mg/1的ATP，胰岛素分泌的增加与浓度的对数呈线性关系。将温度从37.5摄氏度降至28摄氏度会导致由葡萄糖（1.5 g/1）诱导的胰岛素分泌减少。在ATP刺激下，当以ng/min估算时，在28摄氏度时第一阶段测得的胰岛素分泌增加幅度比在37.5摄氏度时弱；然而，当相对于基线值以百分比评估时，在较低温度下这种增加更为显著。
