Houston Todd A, Blanchfield Joanne T
School of Science, Griffith University, Nathan, QLD 4111, Australia.
Mini Rev Med Chem. 2003 Nov;3(7):669-78. doi: 10.2174/1389557033487827.
Certain glycosidase inhibitors possess potent antiviral, antitumour and antidiabetic properties. Glyconic acid lactones, the earliest glycosidase inhibitors identified, have planar anomeric carbons that mimic the transition state of glycoside hydrolysis. Other classes include lactams, glycals, epoxides, halides and sulfonium ions, the latter based on the natural product salacinol from an antidiabetic herb.
某些糖苷酶抑制剂具有强大的抗病毒、抗肿瘤和抗糖尿病特性。最早被鉴定出的糖苷酶抑制剂——糖酸内酯，具有平面异头碳，可模拟糖苷水解的过渡态。其他类别包括内酰胺、烯糖、环氧化物、卤化物和锍离子，后者基于一种抗糖尿病草药中的天然产物沙拉新醇。
