Wabner C L, Pak C Y
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas 75235-8885.
J Am Coll Nutr. 1992 Oct;11(5):548-52. doi: 10.1080/07315724.1992.10718260.
The food-calcium (Ca) interaction was examined in 12 healthy women (mean age 38 years) maintained on a constant metabolic diet. They underwent three phases of study, comprised of control (no Ca), Ca citrate (1 g Ca/day) during meals, and Ca citrate separately from meals. Each phase was 7 days in length and two 24-hour urine samples were collected on days 6 and 7. The rise from the control phase in urinary Ca was slightly more prominent when Ca citrate was given with meals than without (68 and 62%, respectively). The fall in urinary phosphorus was equivalent at about 25% between Ca citrate phases. The rise in urinary citrate and pH and the decline in urinary ammonium were more prominent when Ca citrate was given with meals; however, the changes were small or nonsignificant. The urinary saturation of Ca oxalate, brushite or monosodium urate did not differ between the two Ca citrate phases. There was a nonsignificant rise in serum iron during Ca citrate phases. The results suggest that: 1) dissolution and absorption of Ca citrate might be slightly greater when given with food than without; 2) that the ability of Ca citrate to attenuate crystallization of stone-forming Ca salts in urine is not modified by food; and 3) that Ca citrate may not impair iron absorption from food.
在12名保持恒定代谢饮食的健康女性（平均年龄38岁）中研究了食物与钙（Ca）的相互作用。她们经历了三个研究阶段，包括对照期（无钙）、进餐时服用柠檬酸钙（1克钙/天）以及进餐时不服用柠檬酸钙而单独服用柠檬酸钙。每个阶段持续7天，并在第6天和第7天收集两份24小时尿液样本。与不与餐同服相比，进餐时服用柠檬酸钙时，尿钙较对照期的升高略更显著（分别为68%和62%）。柠檬酸钙各阶段尿磷下降约25%，二者相当。进餐时服用柠檬酸钙时，尿柠檬酸和pH值升高以及尿铵下降更为显著；然而，这些变化较小或不显著。两个柠檬酸钙阶段之间草酸钙、透钙磷石或尿酸钠的尿饱和度没有差异。柠檬酸钙阶段血清铁有不显著升高。结果表明：1）与不与食物同服相比，与食物同服时柠檬酸钙的溶解和吸收可能略高；2）食物不会改变柠檬酸钙减弱尿中结石形成钙盐结晶的能力；3）柠檬酸钙可能不会损害食物中铁的吸收。
