Lian J B, Stein G S
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.
Curr Pharm Des. 2003;9(32):2677-85. doi: 10.2174/1381612033453659.
Runx2/Cbfa/AML3 is a member of the runt homology domain family of transcription factors, essential for osteoblast differentiation and bone formation. Defining the molecular mechanisms by which Runx2 can function as a master regulatory gene for activating the program of osteoblastogenesis has provided novel insights for transcriptional regulation of tissue-specific genes. Regulation of Runx expression has the potential to serve as a basis for the design of novel therapeutic strategies for promoting bone formation. Here we review the unique properties of Runx2 that mediate several key functions necessary for regulating skeletogenesis, controlling osteoblast growth and differentiation, and integrating the complex pathways required for bone formation and turnover.
Runx2/Cbfa/AML3是转录因子的 runt 同源结构域家族的成员，对成骨细胞分化和骨形成至关重要。确定Runx2作为激活成骨细胞生成程序的主调控基因的分子机制，为组织特异性基因的转录调控提供了新的见解。Runx表达的调控有可能作为设计促进骨形成的新型治疗策略的基础。在这里，我们综述了Runx2的独特特性，这些特性介导了调节骨骼生成、控制成骨细胞生长和分化以及整合骨形成和更新所需的复杂途径所必需的几个关键功能。
