Zhao Tong, Chu Zhuangzhuang, Ma Jun, Ouyang Liping
Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.
Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing 210029, China.
J Funct Biomater. 2022 Jul 25;13(3):103. doi: 10.3390/jfb13030103.
Traditional bone replacement materials have been developed with the goal of directing the osteogenesis of osteoblastic cell lines toward differentiation and therefore achieving biomaterial-mediated osteogenesis, but the osteogenic effect has been disappointing. With advances in bone biology, it has been revealed that the local immune microenvironment has an important role in regulating the bone formation process. According to the bone immunology hypothesis, the immune system and the skeletal system are inextricably linked, with many cytokines and regulatory factors in common, and immune cells play an essential role in bone-related physiopathological processes. This review combines advances in bone immunology with biomaterial immunomodulatory properties to provide an overview of biomaterials-mediated immune responses to regulate bone regeneration, as well as methods to assess the bone immunomodulatory properties of bone biomaterials and how these strategies can be used for future bone tissue engineering applications.
传统骨替代材料的研发目标是引导成骨细胞系的骨生成向分化方向发展，从而实现生物材料介导的骨生成，但成骨效果并不理想。随着骨生物学的发展，人们发现局部免疫微环境在调节骨形成过程中具有重要作用。根据骨免疫学假说，免疫系统和骨骼系统紧密相连，有许多共同的细胞因子和调节因子，免疫细胞在与骨相关的生理病理过程中起着至关重要的作用。本文综述结合了骨免疫学的进展和生物材料的免疫调节特性，概述了生物材料介导的免疫反应以调节骨再生，以及评估骨生物材料骨免疫调节特性的方法，以及这些策略如何用于未来的骨组织工程应用。
