肿瘤坏死因子（TNF）在宿主抗结核防御中的作用：对靶向TNF的免疫疗法的启示。
Role of tumour necrosis factor (TNF) in host defence against tuberculosis: implications for immunotherapies targeting TNF.
作者信息
Ehlers S
机构信息
Molecular Infection Biology, Research Centre Borstel, D-23845 Borstel, Germany.
出版信息
Ann Rheum Dis. 2003 Nov;62 Suppl 2(Suppl 2):ii37-42. doi: 10.1136/ard.62.suppl_2.ii37.
Abstract
Studies in mouse infection models clearly demonstrate tumour necrosis factor (TNF) to be a critical component of both the antibacterially protective and the inflammatory immune response to Mycobacterium tuberculosis. It is therefore not surprising that treatment of patients-for example, those with rheumatoid arthritis-with biological agents interfering with TNF activity have shown an increased risk of reactivating tuberculosis. However, conceivably, TNF targeting biological agents can be developed that because of their particular mode of action and their specific pharmacodynamics may be less likely to have this side effect.
摘要
对小鼠感染模型的研究清楚地表明，肿瘤坏死因子（TNF）是抗结核分枝杆菌的保护性免疫反应和炎症免疫反应的关键组成部分。因此，使用干扰TNF活性的生物制剂治疗患者（例如类风湿性关节炎患者）会增加结核病复发风险也就不足为奇了。然而，可以想象，由于其特定的作用方式和特定的药效学，可能会开发出靶向TNF的生物制剂，其产生这种副作用的可能性较小。
相似文献
1
Role of tumour necrosis factor (TNF) in host defence against tuberculosis: implications for immunotherapies targeting TNF.肿瘤坏死因子（TNF）在宿主抗结核防御中的作用：对靶向TNF的免疫疗法的启示。
Ann Rheum Dis. 2003 Nov;62 Suppl 2(Suppl 2):ii37-42. doi: 10.1136/ard.62.suppl_2.ii37.
2
Limited role for lymphotoxin α in the host immune response to Mycobacterium tuberculosis.淋巴毒素α在宿主对结核分枝杆菌免疫反应中的作用有限。
J Immunol. 2010 Oct 1;185(7):4292-301. doi: 10.4049/jimmunol.1000650. Epub 2010 Sep 3.
3
Update on tuberculosis and other opportunistic infections associated with drugs blocking tumour necrosis factor {alpha}.肿瘤坏死因子α阻断药物相关的结核病及其他机会性感染的最新情况
Ann Rheum Dis. 2005 Nov;64 Suppl 4(Suppl 4):iv29-30. doi: 10.1136/ard.2005.042390.
4
[Risks and side effect reactions during therapy with TNF-alpha blockers. An immunologic analysis].[肿瘤坏死因子-α阻滞剂治疗期间的风险和副作用反应。一项免疫学分析]
Dtsch Med Wochenschr. 2004 Jul 23;129(30):1631-4. doi: 10.1055/s-2004-829005.
5
Risk and prevention of tuberculosis and other serious opportunistic infections associated with the inhibition of tumor necrosis factor.与肿瘤坏死因子抑制相关的结核病及其他严重机会性感染的风险与预防
Nat Clin Pract Rheumatol. 2006 Nov;2(11):602-10. doi: 10.1038/ncprheum0336.
6
The yin and yang of tumor necrosis factor inhibitors.肿瘤坏死因子抑制剂的阴阳特性
Cleve Clin J Med. 2006 Mar;73(3):251-6. doi: 10.3949/ccjm.73.3.251.
7
Contribution of transmembrane tumor necrosis factor to host defense against Mycobacterium bovis bacillus Calmette-guerin and Mycobacterium tuberculosis infections.跨膜肿瘤坏死因子在宿主抵御卡介苗和结核分枝杆菌感染中的作用。
Am J Pathol. 2005 Apr;166(4):1109-20. doi: 10.1016/S0002-9440(10)62331-0.
8
Drug-specific risk of non-tuberculosis opportunistic infections in patients receiving anti-TNF therapy reported to the 3-year prospective French RATIO registry.报告至为期 3 年的前瞻性法国 RATIO 注册研究的接受抗 TNF 治疗患者的非结核性机会性感染的药物特异性风险。
Ann Rheum Dis. 2011 Apr;70(4):616-23. doi: 10.1136/ard.2010.137422. Epub 2010 Dec 21.
9
Serious infections associated with anticytokine therapies in the rheumatic diseases.风湿性疾病中与抗细胞因子疗法相关的严重感染。
J Intensive Care Med. 2004 Nov-Dec;19(6):320-34. doi: 10.1177/0885066604267854.
10
Significant risk and associated factors of active tuberculosis infection in Korean patients with inflammatory bowel disease using anti-TNF agents.使用抗TNF药物的韩国炎症性肠病患者活动性结核感染的重大风险及相关因素。
World J Gastroenterol. 2015 Mar 21;21(11):3308-16. doi: 10.3748/wjg.v21.i11.3308.
引用本文的文献
1
Drug-associated infections and infestations in older adults with tumor necrosis factor-alpha inhibitors: a real-world retrospective and pharmacovigilance study.肿瘤坏死因子-α抑制剂治疗老年患者的药物相关感染和寄生虫感染：一项真实世界回顾性和药物警戒研究
Front Pharmacol. 2025 Apr 30;16:1533902. doi: 10.3389/fphar.2025.1533902. eCollection 2025.
2
A bovine pulmosphere model and multiomics reveal early host response signature in tuberculosis.一种牛肺球模型和多组学揭示了结核病早期宿主反应特征。
Commun Biol. 2025 Apr 4;8(1):559. doi: 10.1038/s42003-025-07883-6.
3
Dairy: Friend or Foe? Bovine Milk-Derived Extracellular Vesicles and Autoimmune Diseases.乳制品：朋友还是敌人？牛源细胞外囊泡与自身免疫性疾病。
Int J Mol Sci. 2024 Oct 26;25(21):11499. doi: 10.3390/ijms252111499.
4
Immunomodulatory, Antioxidant, and Potential Anticancer Activity of the Polysaccharides of the Fungus .真菌多糖的免疫调节、抗氧化和潜在抗癌活性。
Molecules. 2024 Jul 31;29(15):3628. doi: 10.3390/molecules29153628.
5
Correlation of Increased Soluble Tumor Necrosis Factor Receptor 1 with Mortality and Dependence on Treatment in Non-Small-Cell Lung Cancer Patients: A Longitudinal Cohort Study.可溶性肿瘤坏死因子受体1升高与非小细胞肺癌患者死亡率及治疗依赖性的相关性：一项纵向队列研究
Cancers (Basel). 2024 Jan 26;16(3):525. doi: 10.3390/cancers16030525.
6
The Cyclooxygenase 2 Inhibitor Etoricoxib as Adjunctive Therapy in Tuberculosis Impairs Macrophage Control of Mycobacterial Growth.环氧化酶 2 抑制剂依托考昔作为结核病辅助治疗药物会损害巨噬细胞控制分枝杆菌生长的能力。
J Infect Dis. 2024 Mar 14;229(3):888-897. doi: 10.1093/infdis/jiad390.
7
HIV/Mtb Co-Infection: From the Amplification of Disease Pathogenesis to an "Emerging Syndemic".HIV/结核分枝杆菌合并感染：从疾病发病机制的放大到“新兴综合征”
Microorganisms. 2023 Mar 27;11(4):853. doi: 10.3390/microorganisms11040853.
8
TNFα aggravates detrimental effects of SARS-CoV-2 infection in the liver.TNFα 加剧了 SARS-CoV-2 感染对肝脏的有害影响。
Front Immunol. 2023 Mar 31;14:1151937. doi: 10.3389/fimmu.2023.1151937. eCollection 2023.
9
Beyond the Clinic: The Activation of Diverse Cellular and Humoral Factors Shapes the Immunological Status of Patients with Active Tuberculosis.超越临床：多样化的细胞和体液因子的激活塑造活动性结核病患者的免疫状态。
Int J Mol Sci. 2023 Mar 6;24(5):5033. doi: 10.3390/ijms24055033.
10
In-depth systems biological evaluation of bovine alveolar macrophages suggests novel insights into molecular mechanisms underlying infection.对牛肺泡巨噬细胞的深入系统生物学评估为感染潜在分子机制提供了新见解。
Front Microbiol. 2022 Nov 30;13:1041314. doi: 10.3389/fmicb.2022.1041314. eCollection 2022.
本文引用的文献
1
The lymphotoxin beta receptor is critically involved in controlling infections with the intracellular pathogens Mycobacterium tuberculosis and Listeria monocytogenes.淋巴毒素β受体在控制细胞内病原体结核分枝杆菌和单核细胞增生李斯特菌的感染中起着关键作用。
J Immunol. 2003 May 15;170(10):5210-8. doi: 10.4049/jimmunol.170.10.5210.
2
3
Tumor necrosis factor signaling.肿瘤坏死因子信号传导
Cell Death Differ. 2003 Jan;10(1):45-65. doi: 10.1038/sj.cdd.4401189.
4
Histoplasmosis after treatment with anti-tumor necrosis factor-alpha therapy.抗肿瘤坏死因子-α治疗后发生组织胞浆菌病。
Am J Respir Crit Care Med. 2003 May 1;167(9):1279-82. doi: 10.1164/rccm.200206-563OC. Epub 2003 Feb 13.
5
Anti-tumour necrosis factor agents and tuberculosis risk: mechanisms of action and clinical management.抗肿瘤坏死因子药物与结核病风险：作用机制及临床管理
Lancet Infect Dis. 2003 Mar;3(3):148-55. doi: 10.1016/s1473-3099(03)00545-0.
6
New indications for treatment of chronic inflammation by TNF-alpha blockade.通过肿瘤坏死因子-α阻断治疗慢性炎症的新适应症。
Am J Med Sci. 2003 Feb;325(2):75-92. doi: 10.1097/00000441-200302000-00005.
7
Listeria monocytogenes infection as a complication of treatment with tumor necrosis factor alpha-neutralizing agents.单核细胞增生李斯特菌感染作为肿瘤坏死因子α中和剂治疗的并发症。
Arthritis Rheum. 2003 Feb;48(2):319-24. doi: 10.1002/art.10758.
8
Infliximab in the treatment of Crohn's disease: a user's guide for clinicians.英夫利昔单抗治疗克罗恩病：临床医生使用指南
Am J Gastroenterol. 2002 Dec;97(12):2962-72. doi: 10.1111/j.1572-0241.2002.07093.x.
9
Anti-tumor necrosis factor-alpha therapy with infliximab as an alternative to corticosteroids in the treatment of human leukocyte antigen B27-associated acute anterior uveitis.英夫利昔单抗抗肿瘤坏死因子-α疗法作为皮质类固醇的替代疗法用于治疗人类白细胞抗原B27相关的急性前葡萄膜炎。
Ophthalmology. 2002 Dec;109(12):2342-6. doi: 10.1016/s0161-6420(02)01292-7.
10
Side effects of anti-TNF therapy: current knowledge.抗 TNF 治疗的副作用：当前认知
Clin Exp Rheumatol. 2002 Nov-Dec;20(6 Suppl 28):S152-7.
Zotero 插件