Sakurai T, Asakura T, Mizuno A, Matsuda M
Department of Biochemistry, Jikei University School of Medicine, Tokyo, Japan.
J Nutr Sci Vitaminol (Tokyo). 1992 Jun;38(3):227-33. doi: 10.3177/jnsv.38.227.
The absorption of pyridoxamine from the intestine of the mouse was studied in whole animals. [3H]Pyridoxamine was orally administered and the distribution of isotope between the six recognized forms of vitamin B6 was determined in portal blood after the administration. When small doses (1.4 or 14 nmol) were administered, labeled pyridoxamine could hardly be found in the portal blood, although labeled pyridoxal and pyridoxal phosphate were found in the same blood. However, when a large amount (46 or 140 nmol) was given, a significant amount of labeled pyridoxamine was found with labeled pyridoxal and pyridoxal phosphate in the portal blood. These results suggest that a physiological dose of pyridoxamine is rapidly transformed to pyridoxal in the intestinal tissues and then released in the form of pyridoxal into the portal blood.
在完整动物中研究了小鼠肠道对吡哆胺的吸收。口服给予[³H]吡哆胺，并在给药后测定门静脉血中维生素B6六种公认形式之间的同位素分布。当给予小剂量（1.4或14 nmol）时，门静脉血中几乎找不到标记的吡哆胺，尽管在同一血液中发现了标记的吡哆醛和磷酸吡哆醛。然而，当给予大量（46或140 nmol）时，门静脉血中发现大量标记的吡哆胺与标记的吡哆醛和磷酸吡哆醛在一起。这些结果表明，生理剂量的吡哆胺在肠道组织中迅速转化为吡哆醛，然后以吡哆醛的形式释放到门静脉血中。
