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[老年人样本中的膳食钙与脊柱畸形患病率]

[Dietary calcium and the prevalence of spinal deformities in a sample of the elderly population].

作者信息

Grazio Simeon, Korsić Mirko

机构信息

Klinika za reumatologiju, fizikalnu medicinu i rehabilitaciju, Klinicka bolnica Sestre milosrdnice Vinogradska 29, 10000 Zagreb.

出版信息

Lijec Vjesn. 2003 May-Jun;125(5-6):117-24.

Abstract

The aim of the study was to determine the role of calcium intake through nutritional consumption of milk and other milk products currently and in three time periods during life (until 25 years, 25-50 years and 50 years and over) and to relate the results to finding of vertebral deformities in an unselected sample of population of Zagreb (Croatia), aged 50 years and above. Each of 425 recruited individuals (269 women and 156 men) completed interviewer administered questionnaire and had lateral thoracolumbar radiography performed according to a standard protocol. The questions related to number of days in which each subject consumed milk and its products in the last week, and milk consumption in three life-periods. The morphometric measurements of vertebral height were used to determine the occurrence of vertebral deformity according to the method described by McCloskey et al. Adding numbers of days in which each subjects in the last week consumed milk and its products the score ranging from 0-28 was obtained. Between two groups of subjects (group I = score 0-10 and group II = score 11 and over), there was no difference by age, but there was by sex, women being those with greater current consumption of milk products. There was an increased risk of finding vertebral deformity in women appertaining to group I (OR = 3.10, 95% CI = 1.20-7.97), but not for men (OR = 0.93, 95% CI = 0.37-2.35), nor for both sexes (OR = 1.89, 95% CI = 0.99-3.63). There was a statistically significant difference in frequency of drinking milk in period 25-50 years of life, women being again more frequent consumers, but not in other periods of life. There was no correlation in frequency of milk consumption and prevalence of vertebral deformity in any of the periods of life, separately for men and women and taken together. To estimate milk consumption throughout the whole life we added the figures for all three periods of life, getting the score ranging from 3-12. The subjects were divided into two groups, and no increased risk of vertebral deformity was found in those who had been drinking less milk (OR = 1.43, 95% CI = 0.77-2.66). In our study women with currently less dietary calcium intake have greater risk for vertebral deformities. No association was found between frequency of milk consumption throughout the life and prevalence of vertebral deformities.

摘要

本研究的目的是确定当前以及生命中的三个时间段(直至25岁、25 - 50岁和50岁及以上)通过食用牛奶和其他奶制品摄入钙的作用,并将结果与克罗地亚萨格勒布50岁及以上未经过挑选的人群样本中椎骨畸形的发现相关联。425名招募的个体(269名女性和156名男性)每人都完成了由访谈者管理的问卷,并按照标准方案进行了胸腰椎侧位X线摄影。问题涉及每位受试者上周食用牛奶及其制品的天数,以及三个生命阶段的牛奶摄入量。根据McCloskey等人描述的方法,使用椎骨高度的形态测量来确定椎骨畸形的发生情况。将每位受试者上周食用牛奶及其制品的天数相加,得到的分数范围为0 - 28分。在两组受试者(第一组 = 分数0 - 10分,第二组 = 分数11分及以上)之间,年龄无差异,但性别有差异,女性是当前奶制品消费量更大的人群。属于第一组的女性发现椎骨畸形的风险增加(比值比 = 3.10,95%置信区间 = 1.20 - 7.97),但男性没有(比值比 = 0.93,95%置信区间 = 0.37 - 2.35),两性合计也没有(比值比 = 1.89,95%置信区间 = 0.99 - 3.63)。在25 - 50岁生命阶段饮用牛奶的频率存在统计学显著差异,女性再次是更频繁的消费者,但在生命的其他阶段没有。在任何生命阶段,无论男女单独还是合计,牛奶消费频率与椎骨畸形患病率均无相关性。为了估计一生的牛奶消费量,我们将三个生命阶段的数字相加,得到的分数范围为3 - 12分。受试者被分为两组,并在饮用牛奶较少的人群中未发现椎骨畸形风险增加(比值比 = 1.43,95%置信区间 = 0.77 - 2.66)。在我们的研究中,当前饮食钙摄入量较低的女性发生椎骨畸形的风险更大。未发现一生牛奶消费频率与椎骨畸形患病率之间存在关联。

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