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[血液透析患者胆结石的患病率]

[Prevalence of gallstones in patients on hemodialysis].

作者信息

Jakić Marko, Mihaljević Dubravka, Pavlović Drasko, Samardzija Goran, Zibar Lada, Jakić Marijana

机构信息

Klinicka bolnica Osijek, Klinika za urologiju, 31000 Osijek.

出版信息

Lijec Vjesn. 2003 May-Jun;125(5-6):124-8.

Abstract

End-stage renal disease affects all organ systems. Nevertheless, frequency of some pathologic conditions does not differ in end-stage renal disease patients in comparison with their age- and sex-matched controls recruited from general population. The paper presents the results of the survey on the prevalence of gallstones in a relatively big group of hemodialysis patients (n = 114; 49 females, 65 males). The goal of the study was to examine whether the genesis of gallstones could be explained by renal failure itself. Gallstones have been found in 24 of 114 hemodialysis patients (21.05%), predominantly females (n = 14). Gallstones have been found in 28.75% of female patients, and in only 15.38% of male patients. The frequency of gallstones correlated significantly with age of the patients (r = 0.26, p < 0.05), number of pregnancies (r = 0.20, p < 0.005) and deliveries (r = 0.22, p < 0.05). Patients suffering from gallstones were significantly older (60.58 +/- 11.99:51.72 +/- 14.01 years, t = 3.10, p < 0.01), with every third older than 54 affected. The results observed do not differ from the results of other authors that report the morbidity in general population. In conclusion, gallstones in hemodialysis patients show same frequency as in general population and probably result from the same pathophysiologic mechanisms.

摘要

终末期肾病会影响所有器官系统。然而,与从普通人群中招募的年龄和性别匹配的对照组相比,某些病理状况在终末期肾病患者中的发生率并无差异。本文呈现了对一大组血液透析患者(n = 114;49名女性,65名男性)胆结石患病率的调查结果。该研究的目的是检验胆结石的成因是否可以用肾衰竭本身来解释。在114名血液透析患者中有24人(21.05%)发现有胆结石,其中女性居多(n = 14)。女性患者中胆结石的发生率为28.75%,而男性患者中仅为15.38%。胆结石的发生率与患者年龄(r = 0.26,p < 0.05)、妊娠次数(r = 0.20,p < 0.005)和分娩次数(r = 0.22,p < 0.05)显著相关。患有胆结石的患者年龄明显更大(60.58 ± 11.99:51.72 ± 14.01岁,t = 3.10,p < 0.01),每三个患者中就有一个年龄超过54岁。观察到的结果与其他作者报告的普通人群发病率结果并无不同。总之,血液透析患者中胆结石的发生率与普通人群相同,可能由相同的病理生理机制导致。

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