de Glisezinski I, Moro C, Pillard F, Marion-Latard F, Harant I, Meste M, Berlan M, Crampes F, Rivière D
Unité de Recherches sur les Obésités, U586, Institut National de la Santé et de la Recherche Médicale, Institut Louis Bugnard, Centre Hospitalier Universitaire, 31403 Toulouse, France.
Am J Physiol Endocrinol Metab. 2003 Nov;285(5):E984-90. doi: 10.1152/ajpendo.00152.2003.
The aim of this study was to investigate whether endurance training improves lipid mobilization and oxidation in overweight subjects. Eleven young men (25.6 +/- 1.4 yr and body mass index 27.7 +/- 0.2) performed a 4-mo training program consisting of practicing aerobic exercise 5 days/wk. Before and after the training period, lipid oxidation was explored during a 60-min exercise at 50% of peak O2 consumption by use of indirect calorimetry. Lipid mobilization and antilipolytic alpha2-adrenoceptor effect were also studied using the microdialysis method in abdominal subcutaneous adipose tissue (SCAT). After training, plasma nonesterified fatty acid (NEFA) levels, at rest and during exercise, were significantly lower than before (P < 0.001). Lipolysis in SCAT was significantly higher after than before training. An antilipolytic alpha2-adrenoceptor effect in SCAT was underlined during exercise before training and disappeared after. The respiratory exchange ratio was lower after training, i.e., the percentage of lipid oxidation was higher only at rest. The amount of lipid oxidized was higher after training, at rest, and during exercise. Although exercise power was higher after training, the relative intensity was equivalent, as suggested by a similar increase in plasma catecholamine concentrations before and after training. In conclusion, 4-mo training in overweight men improved lipid mobilization through a decrease of antilipolytic alpha2-adrenoceptor effect in SCAT and lipid oxidation during moderate exercise. Training induced a decrease of blood NEFA, predicting better prevention of obesity.
本研究旨在调查耐力训练是否能改善超重受试者的脂质动员和氧化。11名年轻男性（年龄25.6±1.4岁，体重指数27.7±0.2）进行了为期4个月的训练计划，包括每周5天进行有氧运动。在训练期前后，通过间接测热法在以50%峰值耗氧量进行60分钟运动期间探究脂质氧化情况。还使用微透析法研究了腹部皮下脂肪组织（SCAT）中的脂质动员和抗脂解α2-肾上腺素能受体效应。训练后，静息和运动期间的血浆非酯化脂肪酸（NEFA）水平显著低于训练前（P<0.001）。训练后SCAT中的脂肪分解显著高于训练前。训练前运动期间SCAT中存在明显的抗脂解α2-肾上腺素能受体效应，训练后消失。训练后呼吸交换率降低，即仅在静息时脂质氧化百分比更高。训练后静息和运动期间氧化的脂质量更高。尽管训练后运动能力更高，但相对强度相当，训练前后血浆儿茶酚胺浓度的类似升高表明了这一点。总之，超重男性进行4个月的训练通过降低SCAT中抗脂解α2-肾上腺素能受体效应和中等强度运动期间的脂质氧化改善了脂质动员。训练导致血液NEFA降低，预示着对肥胖有更好的预防作用。
