Bouchhima C, Mnif M, Jarraya F, Rekik N, Hachicha J, Abid M
Service d'endocrinologie, EPS Hĕdi Chaker, Sfax, Tunisie.
Presse Med. 2003 Sep 20;32(30):1410-2.
Distal tubular acidosis is associated with auto-immune diseases not specific to organ. The coexistence of distal tubular acidosis and auto-immune thyroid affection is very rare.
A 36-year-old woman exhibiting primary hypothyroidism, Gougerot-Sjögren's syndrome and hypergammaglobulinemia, presented distal tubular acidosis revealed by severe hypokaliemia and complicated by quadriplegia and circulatory arrest. Correcting the thyroid defect did not appear to influence the progression of acidosis.
Based on this observation, one can discuss the pathogenesis of distal tubular acidosis during auto-immune diseases (hypothyroidism, Gougerot-Sjögren's syndrome and monoclonal hypergammaglobulinemia) and its impact on therapy.
远端肾小管酸中毒与非器官特异性自身免疫性疾病相关。远端肾小管酸中毒与自身免疫性甲状腺疾病并存非常罕见。
一名36岁女性,患有原发性甲状腺功能减退、古热洛-舍格伦综合征和高球蛋白血症,因严重低钾血症导致远端肾小管酸中毒,并伴有四肢瘫痪和循环骤停。纠正甲状腺缺陷似乎并未影响酸中毒的进展。
基于这一观察结果,可以探讨自身免疫性疾病(甲状腺功能减退、古热洛-舍格伦综合征和单克隆高球蛋白血症)期间远端肾小管酸中毒的发病机制及其对治疗的影响。