Yarygin V N, Sukhikh G T, Sitnikov V F, Stenina M A, Kuznetsov A B, Poltavtseva R A, Krivov L I, Voevodin D A, Savchuk V I, Revishchin A V, Korochkin L I, Aleksandrova M A
Russian State Medical University, Moscow.
Bull Exp Biol Med. 2003 Jul;136(1):88-92. doi: 10.1023/a:1026009517850.
Human embryonic myogenic precursors were transplanted into muscles of mdx mice with hereditary dystrophin-deficient muscular dystrophy. Transplantation induced the synthesis of human dystrophin. The number of dystrophin-positive fibers progressively decreased, however, some of them were preserved even 5 months after transplantation. Our results indicate that xenogeneic transplantation of embryonic myogenic precursors compensates the genetic defect in dystrophin-deficient mice.
将人类胚胎肌源性前体细胞移植到患有遗传性肌营养不良蛋白缺乏性肌营养不良的mdx小鼠的肌肉中。移植诱导了人类肌营养不良蛋白的合成。然而，肌营养不良蛋白阳性纤维的数量逐渐减少，不过其中一些在移植后5个月仍得以保留。我们的结果表明，胚胎肌源性前体细胞的异种移植可弥补肌营养不良蛋白缺乏小鼠的基因缺陷。
