Wan X Steven, Zhou Zhoazong, Kennedy Ann R, Kopelovich Levy
University of Pennsylvania, Philadelphia, PA 19104-6072, USA.
Oncol Rep. 2003 Nov-Dec;10(6):2009-14.
The effects of nine potential cancer chemopreventive agents on cell growth or clonogenic survival were evaluated in normal human prostate epithelial cells, an immortalized but non-tumorigenic human prostate epithelial cell line (267B1), a human benign prostatic hyperplasia (BPH) cell line (BRF-55T), and a human prostate cancer cell line (267B1/Ki-ras). Of the nine agents tested, 9-cis retinoic acid, liarozole fumarate, phenylenebis(methylene)-selenocyanate (p-XSC), and L-selenomethionine demonstrated much stronger growth inhibitory effects on prostate cancer cells than on the normal prostate epithelial cells, suggesting that these agents may be useful as prostate cancer chemopreventive agents. 9-cis retinoic acid, genistein, liarozole fumarate, p-XSC, L-selenomethionine and vitamin E also showed much stronger growth inhibitory effects on BRF-55T cells than on the normal prostate epithelial cells, indicating that these agents may also be useful for the prevention and treatment of BPH. Difluoromethylornithine (DFMO), DHEA analogue 8354 (fluasterone), and oltipraz did not show strong inhibitory effects on the growth or survival of normal prostate epithelial cells, 267B1 or 267B1/Ki-ras cells, suggesting that these agents may not be effective as prostate cancer preventive or therapeutic agents.
在正常人前列腺上皮细胞、一种永生化但无致瘤性的人前列腺上皮细胞系（267B1）、一种人良性前列腺增生（BPH）细胞系（BRF-55T）和一种人前列腺癌细胞系（267B1/Ki-ras）中，评估了九种潜在的癌症化学预防剂对细胞生长或克隆形成存活的影响。在所测试的九种试剂中，9-顺式维甲酸、富马酸 liarozole、亚甲基双（苯硒基）氰化物（p-XSC）和L-硒代蛋氨酸对前列腺癌细胞的生长抑制作用比对正常前列腺上皮细胞强得多，这表明这些试剂可能用作前列腺癌化学预防剂。9-顺式维甲酸、染料木黄酮、富马酸 liarozole、p-XSC、L-硒代蛋氨酸和维生素E对BRF-55T细胞的生长抑制作用也比对正常前列腺上皮细胞强得多，表明这些试剂也可能对BPH的预防和治疗有用。二氟甲基鸟氨酸（DFMO）、脱氢表雄酮类似物8354（氟睾酮）和奥替普拉对正常前列腺上皮细胞、267B1或267B1/Ki-ras细胞的生长或存活没有显示出强烈的抑制作用，这表明这些试剂可能作为前列腺癌预防或治疗剂无效。
