Sarner Martin
Private Consulting Rooms, University College Hospital, Grafton Way, WC1E 6AU, London, UK.
World J Surg. 2003 Nov;27(11):1192-5. doi: 10.1007/s00268-003-7237-8. Epub 2003 Oct 13.
In treating pancreatic exocrine insufficiency the diagnosis of a cause, wherever possible, is a first step. If there is an obstructing lesion, then its relief may be curative. Adequate management depends on dietary manipulation and enzyme replacement. A reduction in fat intake, with accentuation of protein and carbohydrate consumption, is recommended. For enzyme replacement, enteric-coated microspheres are required, taken with adequate acid-suppression with a proton-pump inhibitor. The enzyme supplements, using standard preparations of pancreatin, usually of porcine source, may be as much as 4 to 8 tablets per meal and should be taken with food. Endocrine insufficiency usually requires insulin.
在治疗胰腺外分泌功能不全时，尽可能找出病因是首要步骤。如果存在梗阻性病变，解除梗阻可能治愈疾病。充分的治疗措施包括饮食调整和酶替代治疗。建议减少脂肪摄入，增加蛋白质和碳水化合物的摄入量。酶替代治疗需要使用肠溶微球，并同时使用质子泵抑制剂充分抑制胃酸分泌。酶补充剂通常使用猪源的标准胰酶制剂，每餐可能需要服用4至8片，应与食物同服。内分泌功能不全通常需要胰岛素治疗。
