衰老的脊柱：骨质疏松性脊柱的新技术与治疗方法
The aging spine: new technologies and therapeutics for the osteoporotic spine.
作者信息
Lane Joseph M, Gardner Michael J, Lin Julie T, van der Meulen Marjolein C, Myers Elizabeth
机构信息
Metabolic Bone Disease Service, Hospital for Special Surgery, New York, New York, USA.
出版信息
Eur Spine J. 2003 Oct;12 Suppl 2(Suppl 2):S147-54. doi: 10.1007/s00586-003-0636-6. Epub 2003 Oct 8.
Abstract
Osteoporosis results in low-energy fractures of the spine. The load necessary to cause a vertebral fracture is determined by the characteristics related to the vertebral body structure, mineral content, and quality of bone. Radiographic techniques centered on dual X-ray absorptiometry (DXA) permit a determination of bone mass and fracture risk. Current medical therapies principally using bisphosphonate and pulsatile PTH profoundly decrease the risk of fracture (50+%). Fall prevention strategies can further decrease the possibility of fracture. A comprehensive approach to osteoporosis can favorably alter the disease.
摘要
骨质疏松症会导致脊柱发生低能量骨折。引起椎体骨折所需的负荷取决于与椎体结构、矿物质含量及骨质质量相关的特征。以双能X线吸收测定法（DXA）为核心的放射学技术可用于确定骨量和骨折风险。目前主要使用双膦酸盐和脉冲式甲状旁腺激素的药物治疗可大幅降低骨折风险（降低50%以上）。预防跌倒的策略可进一步降低骨折的可能性。对骨质疏松症采取综合治疗方法可有效改善病情。
相似文献
1
The aging spine: new technologies and therapeutics for the osteoporotic spine.衰老的脊柱：骨质疏松性脊柱的新技术与治疗方法
Eur Spine J. 2003 Oct;12 Suppl 2(Suppl 2):S147-54. doi: 10.1007/s00586-003-0636-6. Epub 2003 Oct 8.
2
Medical treatment of vertebral osteoporosis.椎体骨质疏松症的医学治疗。
Eur Spine J. 2003 Oct;12 Suppl 2(Suppl 2):S132-41. doi: 10.1007/s00586-003-0608-x. Epub 2003 Sep 17.
3
Aging bone and osteoporosis: strategies for preventing fractures in the elderly.衰老骨骼与骨质疏松症：预防老年人骨折的策略
Arch Intern Med. 2003 Oct 13;163(18):2237-46. doi: 10.1001/archinte.163.18.2237.
4
Vertebral fracture assessment by dual-energy X-ray absorptiometry along with bone mineral density in the evaluation of postmenopausal osteoporosis.双能 X 射线吸收法评估椎体骨折联合骨密度在绝经后骨质疏松症评估中的应用。
Arch Osteoporos. 2020 Feb 24;15(1):25. doi: 10.1007/s11657-020-0688-9.
5
[Large clinical trials for osteoporosis].[骨质疏松症的大型临床试验]
Therapie. 2003 Sep-Oct;58(5):415-20. doi: 10.2515/therapie:2003067.
6
[Osteoporosis: an example of an integrating medicine].[骨质疏松症：整合医学的一个范例]
Praxis (Bern 1994). 2004 Feb 25;93(9):309. doi: 10.1024/0369-8394.93.9.309.
7
Vertebral fractures: a hidden problem of osteoporosis.椎体骨折：骨质疏松症的一个隐匿问题。
Med Sci Monit. 2001 Sep-Oct;7(5):1108-17.
8
Rapid prevention of vertebral fractures associated with osteoporosis.快速预防与骨质疏松症相关的椎体骨折。
Orthopedics. 2005 Mar;28(3):291-8. doi: 10.3928/0147-7447-20050301-14.
9
Effectiveness of anti-osteoporotic drugs to prevent secondary fragility fractures: systematic review and meta-analysis.抗骨质疏松药物预防继发性脆性骨折的有效性：系统评价和荟萃分析。
Osteoporos Int. 2017 Dec;28(12):3289-3300. doi: 10.1007/s00198-017-4175-0. Epub 2017 Aug 2.
10
[Bone diseases with Pain. Osteoporosis].[伴有疼痛的骨病。骨质疏松症]
Clin Calcium. 2007 Apr;17(4):606-12.
引用本文的文献
1
Comprehensive guidelines for prehabilitation in spine surgery.脊柱手术术前康复综合指南。
J Craniovertebr Junction Spine. 2025 Jan-Mar;16(1):5-15. doi: 10.4103/jcvjs.jcvjs_209_24. Epub 2025 Apr 1.
2
Betulinic acid synergically enhances BMP2-induced bone formation via stimulating Smad 1/5/8 and p38 pathways.桦木酸通过刺激Smad 1/5/8和p38信号通路协同增强骨形态发生蛋白2诱导的骨形成。
J Biomed Sci. 2016 May 17;23(1):45. doi: 10.1186/s12929-016-0260-5.
3
Osteocyte: the unrecognized side of bone tissue.成骨细胞：骨组织中被忽视的一面。
Osteoporos Int. 2010 Sep;21(9):1457-69. doi: 10.1007/s00198-010-1194-5. Epub 2010 Mar 4.
4
Deleterious effects of intermittent recombinant parathyroid hormone on cartilage formation in a rabbit microfracture model: a preliminary study.间断性重组甲状旁腺激素对兔微骨折模型软骨形成的不良影响：初步研究。
HSS J. 2010 Feb;6(1):79-84. doi: 10.1007/s11420-009-9134-7. Epub 2009 Sep 10.
本文引用的文献
1
Alendronate treatment in men with primary osteoporosis: a three-year longitudinal study.阿仑膦酸钠治疗男性原发性骨质疏松症：一项为期三年的纵向研究。
Calcif Tissue Int. 2003 Aug;73(2):133-9. doi: 10.1007/s00223-002-1085-7.
2
Association between vertebral fracture and increased mortality in osteoporotic patients.骨质疏松症患者椎体骨折与死亡率增加之间的关联。
J Bone Miner Res. 2003 Jul;18(7):1254-60. doi: 10.1359/jbmr.2003.18.7.1254.
3
Bone regeneration in critical size defects by cell-mediated BMP-2 gene transfer: a comparison of adenoviral vectors and liposomes.通过细胞介导的骨形态发生蛋白-2基因转移修复临界尺寸骨缺损：腺病毒载体与脂质体的比较
Gene Ther. 2003 Jul;10(13):1089-98. doi: 10.1038/sj.gt.3301960.
4
Expression of parathyroid hormone-related peptide and insulin-like growth factor I during rat fracture healing.大鼠骨折愈合过程中甲状旁腺激素相关肽和胰岛素样生长因子I的表达
J Orthop Res. 2003 May;21(3):511-20. doi: 10.1016/S0736-0266(02)00161-4.
5
Therapeutic equivalence of alendronate 35 milligrams once weekly and 5 milligrams daily in the prevention of postmenopausal osteoporosis.
Obstet Gynecol. 2003 Apr;101(4):711-21. doi: 10.1016/s0029-7844(03)00008-5.
6
Diagnosis and treatment of osteoporosis in patients with vertebral compression fractures.椎体压缩性骨折患者骨质疏松症的诊断与治疗
J Am Geriatr Soc. 2003 Apr;51(4):483-91. doi: 10.1046/j.1532-5415.2003.51156.x.
7
FDA orders estrogen safety warnings: agency offers guidance for HRT use.美国食品药品监督管理局下令发布雌激素安全警告：该机构提供激素替代疗法使用指南。
JAMA. 2003 Feb 5;289(5):537-8. doi: 10.1001/jama.289.5.537.
8
A prospective study of discordance in diagnosis of osteoporosis using spine and proximal femur bone densitometry.一项使用脊柱和股骨近端骨密度测量法诊断骨质疏松症不一致性的前瞻性研究。
Osteoporos Int. 2003 Jan;14(1):13-8. doi: 10.1007/s00198-002-1311-1.
9
Short-term, high-dose parathyroid hormone-related protein as a skeletal anabolic agent for the treatment of postmenopausal osteoporosis.短期、高剂量甲状旁腺激素相关蛋白作为一种骨合成代谢剂用于治疗绝经后骨质疏松症。
J Clin Endocrinol Metab. 2003 Feb;88(2):569-75. doi: 10.1210/jc.2002-021122.
10
Bone regeneration with calcium sulfate: evidence for increased angiogenesis in rabbits.硫酸钙促进骨再生：兔血管生成增加的证据
J Oral Implantol. 2002;28(6):273-8. doi: 10.1563/1548-1336(2002)028<0273:BRWCSE>2.3.CO;2.
Zotero 插件