Paquet F, Bailey M R
Institut de Radioprotection et de Sûreté Nucléaire, Département de Protection de la santé de l'Homme et de Dosimétrie, Cedex, France.
Radiat Prot Dosimetry. 2003;105(1-4):627-31. doi: 10.1093/oxfordjournals.rpd.a006316.
Assessments of doses and risks to workers and members of the public exposed to radionuclides require biokinetic and dosimetric models which describe the behaviour of the radionuclides and provide tools for dose calculations. The overall objective of BIODOS is to improve the scientific basis of existing models and to provide new or improved models. One part aims to provide models targeting specific uncertainties, including estimates of doses and risks from radionuclides ingested by adults and children; estimates of the transfer of radionuclides to breast milk and doses to infants; development of systemic models to improve the interpretation of bioassays; and studies of the importance of heterogeneous distribution of dose within tissues and cells. The other part forms a comprehensive research programme on the inhalation of radionuclides and addresses four areas of uncertainty, namely ultrafine particles, inter-subject variation, absorption into blood and clearance mechanisms.
对接触放射性核素的工作人员和公众的剂量及风险评估需要生物动力学和剂量学模型，这些模型描述放射性核素的行为并为剂量计算提供工具。BIODOS的总体目标是改善现有模型的科学基础并提供新的或改进的模型。其中一部分旨在提供针对特定不确定性的模型，包括对成人和儿童摄入放射性核素的剂量和风险估计；放射性核素向母乳的转移及婴儿剂量估计；开发用于改进生物测定解释的系统模型；以及研究组织和细胞内剂量异质分布的重要性。另一部分构成了关于放射性核素吸入的综合研究计划，并解决四个不确定性领域，即超细颗粒、个体间差异、血液吸收和清除机制。
