You Jingsong, Verkade John G
Department of Chemistry, Gilman Hall, Iowa State University, Ames, Iowa 50011, USA.
J Org Chem. 2003 Oct 17;68(21):8003-7. doi: 10.1021/jo034779h.
A new catalyst system for the synthesis of alpha-aryl-substituted nitriles is reported. The bicyclic triaminophosphine P(i-BuNCH(2)CH(2))(3)N (1b) serves as an efficient and versatile ligand for the palladium-catalyzed direct alpha-arylation of nitriles with aryl bromides. Using ligand 1b, ethyl cyanoacetate and primary as well as secondary nitriles are efficiently coupled with a wide variety of aryl bromides possessing electron-rich, electron-poor, electron-neutral, and sterically hindered groups.
报道了一种用于合成α-芳基取代腈的新型催化剂体系。双环三氨基膦P(i-BuNCH(2)CH(2))(3)N（1b）作为一种高效且通用的配体，用于钯催化腈与芳基溴的直接α-芳基化反应。使用配体1b，氰基乙酸乙酯以及伯腈和仲腈能与多种具有富电子、缺电子、电中性和空间位阻基团的芳基溴有效偶联。
