二（二叔丁基膦）钯（II）/三（2-甲基-2-苯基丙基）膦催化的芳基氯的Stille交叉偶联反应

Pd2(dba)3/P(i-BuNCH2CH2)3N-catalyzed Stille cross-coupling of aryl chlorides.

作者信息

Su Weiping, Urgaonkar Sameer, Verkade John G

机构信息

Department of Chemistry, Gilman Hall, Iowa State University, Ames, Iowa 50011, USA.

出版信息

Org Lett. 2004 Apr 29;6(9):1421-4. doi: 10.1021/ol0495927.

DOI:10.1021/ol0495927

Abstract

[reaction: see text] The Pd(2)(dba)(3)/P(i-BuNCH(2)CH(2))(3)N (1d) catalyst system is highly effective for the Stille cross-coupling of aryl chlorides with organotin compounds. This method represents only the second general method for the coupling of aryl chlorides. Other proazaphosphatranes possessing benzyl substituents also generate very active catalysts for Stille reactions. Noteworthy features of the method are: (a) commercial availability of ligand 1d, (b) the wide array of aryl chlorides that can be coupled, and (c) applicability to aryl, vinyl, and allyl tin reagents.

摘要

[反应：见正文] Pd(2)(dba)(3)/P(i-BuNCH(2)CH(2))(3)N（1d）催化剂体系对于芳基氯与有机锡化合物的Stille交叉偶联反应非常有效。该方法是芳基氯偶联反应的第二种通用方法。其他具有苄基取代基的前氮杂环丙烷也能生成用于Stille反应的非常活泼的催化剂。该方法的显著特点有：（a）配体1d可商购；（b）可偶联的芳基氯种类繁多；（c）适用于芳基、乙烯基和烯丙基锡试剂。

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