酵母G蛋白α亚基Gpa1通过一种RNA结合效应蛋白Scp160传递信号。
The yeast G protein alpha subunit Gpa1 transmits a signal through an RNA binding effector protein Scp160.
作者信息
Guo Ming, Aston Christopher, Burchett Scott A, Dyke Christine, Fields Stanley, Rajarao S Johannes R, Uetz Peter, Wang Yuqi, Young Kathleen, Dohlman Henrik G
机构信息
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
出版信息
Mol Cell. 2003 Aug;12(2):517-24. doi: 10.1016/s1097-2765(03)00307-1.
In yeast Saccharomyces cerevisiae the G protein betagamma subunits (Ste4/Ste18) have long been known to transmit the signal required for mating. Here we demonstrate that GTPase-deficient mutants of Galpha (Gpa1) directly activate the mating response pathway. We also show that signaling by activated Gpa1 requires direct coupling to an RNA binding protein Scp160. These findings suggest an additional role for Gpa1 and reveal Scp160 as a component of the mating response pathway in yeast.
在酿酒酵母中，G蛋白βγ亚基（Ste4/Ste18）长期以来被认为可传递交配所需的信号。在此我们证明，Gα（Gpa1）的GTP酶缺陷型突变体可直接激活交配反应途径。我们还表明，活化的Gpa1发出的信号需要直接与RNA结合蛋白Scp160偶联。这些发现表明Gpa1具有额外的作用，并揭示Scp160是酵母交配反应途径的一个组成部分。
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