Mazzarella V, Gallucci M T, Tozzo C, Elli M, Chiavarelli R, Marino B, Casciani C
Istituto di Tipizzaazione Tissutale e problemi della dialisi-CNR di L'Aquila, Rome, Italy.
J Thorac Cardiovasc Surg. 1992 Dec;104(6):1625-7.
We evaluate short- and long-term effects on renal functional reserve of cardiopulmonary bypass in 11 patients. A selected group (persistence of renal functional reserve before operation) of 11 adult patients undergoing cardiopulmonary bypass for aorta-coronary bypass were studied. Renal functional reserve tests were performed in all patients before the operation, at postoperative day 9, and at 6 months after operation. Basal glomerular filtration rate did not show significant changes at 9 days and at 6 months after operation. On the contrary, renal functional reserve was absent at 9 days, but it was restored to preoperative levels at 6 months after operation. In conclusion, our data indicate that cardiopulmonary bypass probably causes renal damage that is not sufficient to influence routine renal function parameters.
我们评估了11例患者体外循环对肾功能储备的短期和长期影响。选取了11例接受主动脉-冠状动脉搭桥体外循环手术的成年患者（术前存在肾功能储备）进行研究。在所有患者术前、术后第9天和术后6个月进行了肾功能储备测试。术后9天和6个月时，基础肾小球滤过率未显示出显著变化。相反，术后9天肾功能储备消失，但术后6个月恢复到术前水平。总之，我们的数据表明体外循环可能会导致肾脏损伤，但这种损伤不足以影响常规肾功能参数。
