Heim F
Aktuelle Gerontol. 1976 Jul;6(7):329-35.
Four examples (Methamphetamine, Testosterone, Caffeine, Cysteamine) have demonstrated that the response of the organism to a drug is primarily dependent upon the functional status of the organ concerned. If this functional status changes with age, then accordingly the reaction to the drug also changes. If, however, one alters the functional status of an organ in the elderly organism, e.g. inducing increased production of DNA in the liver by partial hepatectomy, the reaction of the organ now follows a pattern comparable to the juvenile organism, rather than being dependent on chronological age.
四个例子（甲基苯丙胺、睾酮、咖啡因、半胱胺）表明，生物体对药物的反应主要取决于相关器官的功能状态。如果这种功能状态随年龄变化，那么对药物的反应也会相应改变。然而，如果改变老年生物体中某个器官的功能状态，例如通过部分肝切除术诱导肝脏中DNA产量增加，该器官的反应现在遵循与幼年生物体类似的模式，而不是取决于实际年龄。
