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[疫苗接种后腮腺炎。疫情暴发中的流行病学模式及疫苗效力]

[Parotiditis in postvaccination period. Epidemiologic pattern and vaccine effectiveness in an epidemic outbreak].

作者信息

Guimbao Bescós J, Moreno Marín M P, Gutiérrez Colás V, Pac Sá M R, Arribas Monzón F

出版信息

Med Clin (Barc). 1992 Sep 19;99(8):281-5.

PMID:1453820
Abstract

BACKGROUND

Upon the detection of an excess number of cases of parotiditis in La Almolda (Zaragoza) a descriptive study of the epidemic was carried out with vaccination efficacy being quantified.

METHODS

The definition and system of detection of the cases was established. To calculate the rate of infection the available demographic data were used as denominators. A study of retrospective groups was designed to calculate the vaccination efficacy including one group of vaccinated subjects and another of non vaccinated subjects. Age and viral contact were considered as inclusion criteria.

RESULTS

Fifty-two cases of parotiditis were detected. The rate of infection in a population of under 30 years of age was 18.9%. The most affected age group corresponded to the interval of between 10-14 years of age with a specific rate of 46.5%. The risk of infection was greatest amongst public school students (RR = 5; p = 0.00015). Vaccination efficacy was 74.68%.

CONCLUSIONS

This study confirms the tendency that parotiditis affects older subjects during the prevaccination period. The vaccination efficacy found to be 74.68% was lower the efficacy determined from seroconversion studies.

摘要

背景

在拉阿尔莫尔达(萨拉戈萨)检测到腮腺炎病例数量过多后,对该疫情进行了描述性研究,并对疫苗接种效果进行了量化。

方法

确定了病例的定义和检测系统。以现有人口统计数据作为分母来计算感染率。设计了一项回顾性分组研究来计算疫苗接种效果,包括一组接种疫苗的受试者和另一组未接种疫苗的受试者。年龄和病毒接触情况被视为纳入标准。

结果

检测到52例腮腺炎病例。30岁以下人群的感染率为18.9%。受影响最严重的年龄组为10至14岁年龄段,特定感染率为46.5%。公立学校学生的感染风险最高(相对危险度=5;p=0.00015)。疫苗接种效果为74.68%。

结论

本研究证实了腮腺炎在疫苗接种前时期影响年龄较大人群的趋势。发现的74.68%的疫苗接种效果低于血清转化研究确定的效果。

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