Bruguerolle B, Emperaire N
Laboratoire de Pharmacologie Médicale, Faculté de Médecine de Marseille, France.
Life Sci. 1992;51(25):I-IV. doi: 10.1016/0024-3205(92)90121-5.
The purpose of this study was to investigate the influence of flumazenil on local anesthetic-induced acute toxicity. For each of the three tested anesthetics (etidocaine, mepivacaine and lidocaine) 6 groups of mice were treated by a single dose of flumazenil (0.125, 0.25, 0.5, 1 and 2 mg/kg), or an equal volume of saline, 15 minutes before the injection of the anesthetic (etidocaine: 50 mg/kg, mepivacaine: 110 mg/kg and lidocaine: 115 mg/kg). The convulsant activity, the time of latency to convulse and the mortality rate were assessed in each group. The local anesthetic-induced mortality was not significantly modified by flumazenil. The convulsant activity of lidocaine and mepivacaine was significantly increased by flumazenil but not for etidocaine. Also, increasing doses of flumazenil decreased the time of latency to obtain lidocaine-induced convulsions. This effect was not obtained with etidocaine or mepivacaine.
本研究的目的是探讨氟马西尼对局部麻醉药所致急性毒性的影响。对于三种受试麻醉药（依替卡因、甲哌卡因和利多卡因）中的每一种，在注射麻醉药（依替卡因：50mg/kg、甲哌卡因：110mg/kg和利多卡因：115mg/kg）前15分钟，用单剂量的氟马西尼（0.125、0.25、0.5、1和2mg/kg）或等体积的生理盐水对6组小鼠进行处理。评估每组的惊厥活性、惊厥潜伏期和死亡率。氟马西尼对局部麻醉药所致的死亡率没有显著影响。氟马西尼可显著增加利多卡因和甲哌卡因的惊厥活性，但对依替卡因无效。此外，氟马西尼剂量增加可缩短利多卡因诱发惊厥的潜伏期。依替卡因或甲哌卡因未出现这种效应。
