在系统性红斑狼疮中，抗核仁素自身抗体与组蛋白H1发生交叉反应。
Autoantibodies to nucleolin cross-react with histone H1 in systemic lupus erythematosus.
作者信息
Jarjour W N, Minota S, Roubey R A, Mimura T, Winfield J B
机构信息
Thurston Arthritis Research Center, University of North Carolina, Chapel Hill 27599-7280.
出版信息
Mol Biol Rep. 1992 Sep;16(4):263-6. doi: 10.1007/BF00419666.
IgM autoantibodies to nucleolin and histone H1 are strongly associated in the serum of patients with systemic lupus erythematosus. IgM eluted from immobilized nucleolin specifically stained histone H1 blotted to nitrocellulose; conversely, IgM eluates prepared from immobilized histone H1 stained nucleolin blots. We conclude that the linkage of anti-nucleolin and anti-histone H1 autoantibodies in SLE is due, at least in part, to immunologic cross-reactivity between these two autoantigens, which share certain similar structural features.
系统性红斑狼疮患者血清中针对核仁素和组蛋白H1的IgM自身抗体密切相关。从固定化核仁素上洗脱的IgM能特异性地染色转移至硝酸纤维素膜上的组蛋白H1；相反，从固定化组蛋白H1制备的IgM洗脱液能染色核仁素印迹。我们得出结论，系统性红斑狼疮中抗核仁素和抗组蛋白H1自身抗体的关联，至少部分是由于这两种自身抗原之间的免疫交叉反应性，它们具有某些相似的结构特征。
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