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一个单细胞核基因决定了植物线粒体转录本RNA编辑的丰度和程度。

A single nuclear gene specifies the abundance and extent of RNA editing of a plant mitochondrial transcript.

作者信息

Lu B, Hanson M R

机构信息

Section of Genetics and Development, Cornell University, Ithaca, NY 14853.

出版信息

Nucleic Acids Res. 1992 Nov 11;20(21):5699-703. doi: 10.1093/nar/20.21.5699.

DOI:10.1093/nar/20.21.5699
PMID:1454533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC334405/
Abstract

A number of cytosines are altered to be recognized as uridines in transcripts of the NADH-dehydrogenase subunit 3 (nad3) gene in the mitochondria of the higher plant Petunia hybrida. Here we show that the extent of editing for three of the edit sites, all of which change the encoded amino acid, varies between different Petunia lines. Genetic analysis indicates that a single nuclear gene is responsible for this variation. Interestingly, according to RNA blot hybridization analysis, RNA editing extent and transcript abundance are correlated. This observation is consistent with the hypothesis that RNA editing is a post-transcriptional event.

摘要

在高等植物矮牵牛的线粒体中，NADH脱氢酶亚基3（nad3）基因转录本中的许多胞嘧啶被改变为尿嘧啶。我们在此表明，3个编辑位点的编辑程度在不同矮牵牛品系间存在差异，这3个位点均改变了编码的氨基酸。遗传分析表明，单个核基因导致了这种差异。有趣的是，根据RNA印迹杂交分析，RNA编辑程度与转录本丰度相关。这一观察结果与RNA编辑是转录后事件的假说一致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cdb/334405/17c564f3fabb/nar00232-0187-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cdb/334405/5980acfe472c/nar00232-0185-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cdb/334405/a4ec64aa2994/nar00232-0186-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cdb/334405/17c564f3fabb/nar00232-0187-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cdb/334405/5980acfe472c/nar00232-0185-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cdb/334405/a4ec64aa2994/nar00232-0186-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cdb/334405/17c564f3fabb/nar00232-0187-a.jpg

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