Deuchar E M
J Embryol Exp Morphol. 1977 Oct;41:93-9.
Diabetes mellitus was induced in female Wistar rats by injections of either alloxan or streptozotocin, and their embryos were found to have significantly higher incidences (7.5%) of brain and heart abnormalities (non-closure of neural folds, and deformities of heart chambers) at mid-gestation than controls (2.2%). There were also increased numbers of resorptions (25% in diabetic animals: 7.2% in controls). Both drugs produced similar abnormalities. External and X-ray examination of 488 foetuses from streptozotocin-treated animals at 20 days showed eight cases of exomphalos, two cases of micrognathia with tongue protrusion, and 34 cases of incomplete sacral ossification. This last deformity occurred also in foetuses of mildly diabetic animals, and has been seen occasionally in infants of human diabetic mothers. Other evidence suggests that skeletal deformities may be due to hyperinsulinism in the foetuses of diabetic mothers. Even a mild or pre-diabetic condition may set the foetus at risk.
通过注射四氧嘧啶或链脲佐菌素诱导雌性Wistar大鼠患糖尿病，发现它们的胚胎在妊娠中期出现脑和心脏异常（神经褶未闭合、心腔畸形）的发生率（7.5%）显著高于对照组（2.2%）。吸收的数量也增加了（糖尿病动物中为25%，对照组为7.2%）。两种药物产生的异常情况相似。对链脲佐菌素处理动物的488个胎儿在20天时进行外部和X射线检查，发现8例脐膨出、2例小颌伴舌突出以及34例骶骨不完全骨化。最后一种畸形也出现在轻度糖尿病动物的胎儿中，并且偶尔在人类糖尿病母亲的婴儿中也可见到。其他证据表明，骨骼畸形可能是由于糖尿病母亲胎儿的高胰岛素血症所致。即使是轻度或糖尿病前期状况也可能使胎儿处于危险之中。
