Zs-Nagy V, Zs-Nagy I, Pieri C, Del Moro M
Aktuelle Gerontol. 1977 Jan;7(1):19-22.
It has been shown that the thermal stability of DNA in the brain cortical cells increases with the age. At the same time, the number of perichromatin granules being connected in some way to the messenger RNA synthesis and transport of the interphase nuclei, decreases in the same cells. In vivo treatment of the old animals by mitogens like phytohemagglutinin induced a reversal of both ageing phenomena: the thermal stability of DNA returned almost completely to that of the young animals, whereas the number of perichromatin granules rised again to the young level.
研究表明，大脑皮层细胞中DNA的热稳定性随年龄增长而增加。与此同时，在相同细胞中，以某种方式与间期细胞核的信使核糖核酸合成和运输相关的染色质周围颗粒数量减少。用植物血凝素等有丝分裂原对老龄动物进行体内处理，可使这两种衰老现象发生逆转：DNA的热稳定性几乎完全恢复到幼龄动物的水平，而染色质周围颗粒的数量也再次上升至幼龄水平。
