Synthesis and biological evaluation of 4-[(3-methyl-3H-imidazol-4-yl)-(2-phenylethynyl-benzyloxy)-methyl]-benzonitrile as novel farnesyltransferase inhibitor.

作者信息

Lin Nan-Horng, Wang Le, Cohen Jerry, Gu Wen-Zhen, Frost David, Zhang Haiying, Rosenberg Saul, Sham Hing

机构信息

Cancer Research, R-47B, Global Pharmaceutical Products Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-3500, USA.

出版信息

Bioorg Med Chem Lett. 2003 Nov 3;13(21):3821-5. doi: 10.1016/j.bmcl.2003.07.006.

DOI:10.1016/j.bmcl.2003.07.006

PMID:14552788

Abstract

Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anticancer agents. Analogues of the potent FTI, 4-[3-biphenyl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile, were synthesized and tested in vitro for their inhibitory activities. The most promising compound identified from this series is analogue 11 that possesses potent enzymatic and cellular activities.

摘要

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