Tong Yunsong, Lin Nan-Horng, Wang Le, Hasvold Lisa, Wang Weibo, Leonard Nicholas, Li Tongmei, Li Qun, Cohen Jerry, Gu Wen-Zhen, Zhang Haiying, Stoll Vincent, Bauch Joy, Marsh Kennan, Rosenberg Saul H, Sham Hing L
R47B, AP10, Global Pharmaceutical R&D, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6101, USA.
Bioorg Med Chem Lett. 2003 May 5;13(9):1571-4. doi: 10.1016/s0960-894x(03)00195-1.
A pyridyl moiety was introduced into a previously developed series of farnesyltransferase inhibitors containing imidazole and cyanophenyl (such as 4), resulting in potent inhibitors with improved pharmacokinetics.
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