肾内输注重组人促红细胞生成素对麻醉兔平均动脉压和肾血流动力学的影响。

The effects of intrarenal infusion of recombinant human erythropoietin on mean arterial pressure and renal hemodynamics in anesthetized rabbits.

作者信息

Nushiro N, Abe K, Misawa S, Seino M, Omata K, Imai Y, Sekino H, Yoshinaga K

机构信息

Department of Clinical Biology and Hormonal Regulation, Tohoku University School of Medicine, Sendai, Japan.

出版信息

Tohoku J Exp Med. 1992 May;167(1):19-25. doi: 10.1620/tjem.167.19.

DOI:10.1620/tjem.167.19

PMID:1455417

Abstract

The effects of recombinant human erythropoietin (rHuEPO) on mean arterial pressure (MAP) and renal hemodynamics were studied in anesthetized rabbits without renal failure. Intrarenal infusion of rHuEPO at a rate of 100 U/min for 30 min resulted in no change in MAP, renal blood flow, or renal vascular resistance. rHuEPO also produced no significant change in glomerular filtration rate filtration fraction, or arterial hematocrit. These results demonstrate that rHuEPO has no direct effects on MAP or renal hemodynamics in anesthetized rabbits without renal failure.

摘要

在无肾衰竭的麻醉兔中研究了重组人促红细胞生成素（rHuEPO）对平均动脉压（MAP）和肾血流动力学的影响。以100 U/分钟的速率肾内输注rHuEPO 30分钟，MAP、肾血流量或肾血管阻力均无变化。rHuEPO对肾小球滤过率、滤过分数或动脉血细胞比容也无显著影响。这些结果表明，rHuEPO对无肾衰竭的麻醉兔的MAP或肾血流动力学无直接影响。