Nushiro N, Sakamaki T, Misawa S, Seino M, Omata K, Imai Y, Sekino H, Murata K, Abe K
Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
Nihon Jinzo Gakkai Shi. 1993 Feb;35(2):125-31.
To determine whether recombinant human erythropoietin (rHuEPO) has direct effect on mean arterial pressure or renal function, rHuEPO was infused intrarenally at a rate of 100 U min-1 for 30 min in anesthetized rabbits without renal failure. Intrarenal infusion of rHuEPO resulted in no change in mean arterial pressure, renal blood flow, or renal vascular resistance as compared with vehicle control. rHuEPO also produced no significant change in glomerular filtration rate, filtration fraction, or arterial hematocrit. However, urine volume, urinary excretion of sodium and potassium, and fractional sodium excretion were significantly reduced by intrarenal infusion of rHuEPO. These observations demonstrate that rHuEPO has no direct effects on mean arterial pressure or renal hemodynamics, whereas rHuEPO stimulates net tubular sodium reabsorption possibly by direct tubular action, and reduces urine volume and urinary excretion of sodium and potassium in anesthetized rabbits without renal failure.
为了确定重组人促红细胞生成素（rHuEPO）对平均动脉压或肾功能是否有直接影响，在无肾衰竭的麻醉兔中，以100 U/min的速率肾内输注rHuEPO 30分钟。与载体对照相比，肾内输注rHuEPO后平均动脉压、肾血流量或肾血管阻力均无变化。rHuEPO对肾小球滤过率、滤过分数或动脉血细胞比容也无显著影响。然而，肾内输注rHuEPO可使尿量、尿钠和钾排泄量以及钠排泄分数显著降低。这些观察结果表明，rHuEPO对平均动脉压或肾血流动力学无直接影响，而rHuEPO可能通过直接作用于肾小管刺激肾小管钠重吸收，并减少无肾衰竭麻醉兔的尿量及尿钠和钾排泄量。
