Ringel S P, Engel W K, Bender A N, Peters N D, Yee R D
Neurology. 1978 Jan;28(1):55-63. doi: 10.1212/wnl.28.1.55.
In monkey extraocular muscles (EOM), a battery of histochemical reactions delineates three muscle fiber types, coarse, fine, and granular. Normal EOM are compared with EOM denervated by intracranial oculomotor nerve section. The experimentally denervated EOM fibers did not show the constellation of histologic responses typical of denervated limb muscle, making a diagnosis of a denervation process in EOM muscle very difficult. Although the denervated fine and granular fibers (but not the coarse fibers) develop diffuse extrajunctional acetylcholine receptors (AChR) following experimental denervation, this is not a reliable criterion of denervation because not all of those fibers developed it and they did not show it beyond a 12-week period following nerve section; moreover, myopathic mechanisms have previously been shown capable of provoking diffuse extrajunctional AChR in limb-muscle fibers.
在猴眼外肌（EOM）中，一系列组织化学反应可区分出三种肌纤维类型，即粗肌纤维、细肌纤维和颗粒状肌纤维。将正常的眼外肌与因颅内动眼神经切断而失神经支配的眼外肌进行比较。实验性失神经支配的眼外肌纤维并未表现出失神经支配的肢体肌肉典型的一系列组织学反应，这使得诊断眼外肌的失神经支配过程非常困难。尽管实验性失神经支配后，失神经的细肌纤维和颗粒状肌纤维（但粗肌纤维未出现）会出现弥漫性接头外乙酰胆碱受体（AChR），但这并非失神经支配的可靠标准，因为并非所有这些纤维都会出现这种情况，并且在神经切断后的12周后它们也不再表现出这种情况；此外，先前已证明肌病机制能够在肢体肌肉纤维中引发弥漫性接头外AChR。
