Goda Yukiko, Davis Graeme W
MRC Cell Biology Unit and Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom.
Neuron. 2003 Oct 9;40(2):243-64. doi: 10.1016/s0896-6273(03)00608-1.
The mechanisms that govern synapse formation and elimination are fundamental to our understanding of neural development and plasticity. The wiring of neural circuitry requires that vast numbers of synapses be formed in a relatively short time. The subsequent refinement of neural circuitry involves the formation of additional synapses coincident with the disassembly of previously functional synapses. There is increasing evidence that activity-dependent plasticity also involves the formation and disassembly of synapses. While we are gaining insight into the mechanisms of both synapse assembly and disassembly, we understand very little about how these phenomena are related to each other and how they might be coordinately controlled to achieve the precise patterns of synaptic connectivity in the nervous system. Here, we review our current understanding of both synapse assembly and disassembly in an effort to unravel the relationship between these fundamental developmental processes.
支配突触形成与消除的机制是我们理解神经发育和可塑性的基础。神经回路的布线要求在相对较短的时间内形成大量突触。随后神经回路的精细化涉及到在先前功能正常的突触拆解的同时形成额外的突触。越来越多的证据表明，活动依赖的可塑性也涉及突触的形成和拆解。虽然我们对突触组装和拆解的机制有了更多了解，但我们对这些现象如何相互关联以及它们如何被协调控制以实现神经系统中精确的突触连接模式却知之甚少。在这里，我们回顾了我们目前对突触组装和拆解的理解，试图揭示这些基本发育过程之间的关系。
