泛素-26S蛋白酶体途径在赤霉素信号传导中的作用。

A role for the ubiquitin-26S-proteasome pathway in gibberellin signaling.

作者信息

Itoh Hironori, Matsuoka Makoto, Steber Camille M

机构信息

Bioscience and Biotechnology Center, Nagoya University, Chikusa, Nagoya 464-8601, Japan.

出版信息

Trends Plant Sci. 2003 Oct;8(10):492-7. doi: 10.1016/j.tplants.2003.08.002.

DOI:10.1016/j.tplants.2003.08.002

PMID:14557046

Abstract

The gibberellin (GA) signaling pathway, like auxin and jasmonate signaling, uses the ubiquitin-proteasome pathway to control expression through protein degradation. A conserved F-box protein of an SCF E3 ubiquitin ligase is a positive regulator of GA signaling in Arabidopsis and rice. GA apparently stimulates stem elongation by causing this SCF complex to regulate negatively a family of negative regulators of GA response (the DELLA family of putative transcription factors). The DELLA family members AtRGA or (Repressor of ga1-3) and OsSLR1 (SLENDER RICE1) proteins both appear to be subject to GA-induced proteolysis. The need to have the F-box genes AtSLY1 and OsGID2 for this proteolysis suggests that GA causes proteolysis of AtRGA/OsSLR1 via the SCF(AtSLY1/OsGID2) ubiquitin ligase.

摘要

赤霉素（GA）信号通路与生长素和茉莉酸信号通路一样，利用泛素-蛋白酶体通路通过蛋白质降解来控制基因表达。拟南芥和水稻中，SCF E3泛素连接酶的一个保守F-box蛋白是GA信号通路的正向调节因子。GA显然通过促使该SCF复合体对GA反应的一类负调节因子（假定转录因子的DELLA家族）进行负调控，从而刺激茎的伸长。DELLA家族成员AtRGA或（ga1-3的阻遏物）以及OsSLR1（细长水稻1）蛋白似乎都受到GA诱导的蛋白水解作用。这种蛋白水解作用需要F-box基因AtSLY1和OsGID2，这表明GA通过SCF(AtSLY1/OsGID2)泛素连接酶导致AtRGA/OsSLR1的蛋白水解。