Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China.
Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes, Department of Biology, Institute of Plant and Food Science, Southern University of Science and Technology, Shenzhen 518055, China.
Int J Mol Sci. 2021 Sep 24;22(19):10304. doi: 10.3390/ijms221910304.
Basic helix-loop-helix (bHLH) family transcription factor PHYTOCHROME INTERACTING FACTOR 4 (PIF4) is necessary for plant adaption to light or high ambient temperature. PIF4 directly associates with plenty of its target genes and modulates the global transcriptome to induce or reduce gene expression levels. However, PIF4 activity is tightly controlled by its interacting proteins. Until now, twenty-five individual proteins have been reported to physically interact with PIF4. These PIF4-interacting proteins act together with PIF4 and form a unique nexus for plant adaption to light or temperature change. In this review, we will discuss the different categories of PIF4-interacting proteins, including photoreceptors, circadian clock regulators, hormone signaling components, and transcription factors. These distinct PIF4-interacting proteins either integrate light and/or temperature cues with endogenous hormone signaling, or control PIF4 abundances and transcriptional activities. Taken together, PIF4 and PIF4-interacting proteins play major roles for exogenous and endogenous signal integrations, and therefore establish a robust network for plants to cope with their surrounding environmental alterations.
基本螺旋-环-螺旋 (bHLH) 家族转录因子 PHYTOCHROME INTERACTING FACTOR 4 (PIF4) 对于植物适应光照或环境高温是必需的。PIF4 直接与大量的靶基因结合，并调节全转录组以诱导或降低基因表达水平。然而，PIF4 的活性受到其相互作用蛋白的严格控制。到目前为止，已经有二十五个单独的蛋白质被报道与 PIF4 发生物理相互作用。这些 PIF4 相互作用蛋白与 PIF4 一起作用，形成一个独特的节点，使植物能够适应光照或温度变化。在这篇综述中，我们将讨论不同类别的 PIF4 相互作用蛋白，包括光受体、生物钟调节器、激素信号成分和转录因子。这些不同的 PIF4 相互作用蛋白要么整合光和/或温度信号与内源性激素信号，要么控制 PIF4 的丰度和转录活性。总之，PIF4 和 PIF4 相互作用蛋白在外源和内源信号整合中发挥重要作用，因此为植物应对周围环境变化建立了一个强大的网络。
