血清素受体3A（HTR3A）基因多态性及其与女性回避伤害的关联。
A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women.
作者信息
Melke Jonas, Westberg Lars, Nilsson Staffan, Landen Mikael, Soderstrom Henrik, Baghaei Fariba, Rosmond Roland, Holm Göran, Björntorp Per, Nilsson Lars-Göran, Adolfsson Rolf, Eriksson Elias
机构信息
Departments of Pharmacology, Göteborg University, Göteborg, Sweden.
出版信息
Arch Gen Psychiatry. 2003 Oct;60(10):1017-23. doi: 10.1001/archpsyc.60.10.1017.
BACKGROUND
The brain neurotransmitter serotonin is known to affect various aspects of human behavior, including personality traits. Serotonin receptor type 3 is a ligand-gated channel encoded by 2 different subunit genes, HTR3A and HTR3B. A polymorphism (C178T) in the 5' region of the HTR3A gene has recently been identified and suggested to be of functional importance.
OBJECTIVE
To elucidate the possible association between the C178T polymorphism in the HTR3A gene and personality traits in women.
DESIGN
Two independent samples of 35- to 45-year-old Swedish women were recruited using the population register. Sample 1 (n = 195) was assessed via the Karolinska Scales of Personality and the Temperament and Character Inventory; sample 2 (n = 175) was assessed using the latter only. Both samples were genotyped with respect to the C178T polymorphism in the HTR3A gene. The A1596G polymorphism in the same gene was also investigated.
RESULTS
A significant association between C178T genotype and the Temperament and Character Inventory factor harm avoidance was observed in sample 1 (corrected for multiple comparisons P =.04); this finding was subsequently replicated in sample 2 (P =.004) (pooled populations: P<.001). In the pooled sample, all harm avoidance subscales were found to be significantly associated with the C178T polymorphism: anticipatory worry (P =.001), fear of uncertainty (P<.001), shyness (P<.001), and fatigability and asthenia (P =.008). In addition, a significant association was found in sample 1 between the C178T polymorphism and the Karolinska Scales of Personality nonconformity factor (corrected P =.002), including the subscales of social desirability (P<.001), indirect aggression (P =.002), verbal aggression (P =.05), and irritability (P<.001). Participants homozygous for the less common T allele (<4%) differed from the remaining women by displaying lower ratings on harm avoidance and nonconformity.
CONCLUSION
The C178T polymorphism in the HTR3A gene may affect the personality trait of harm avoidance in women.
背景
已知大脑神经递质血清素会影响人类行为的各个方面，包括人格特质。血清素3型受体是一种配体门控通道，由2种不同的亚基基因HTR3A和HTR3B编码。最近在HTR3A基因5'区域发现了一种多态性（C178T），并提示其具有功能重要性。
目的
阐明HTR3A基因C178T多态性与女性人格特质之间的可能关联。
设计
使用人口登记册招募了两组独立的35至45岁瑞典女性样本。样本1（n = 195）通过卡罗林斯卡人格量表和气质与性格问卷进行评估；样本2（n = 175）仅使用后者进行评估。对两组样本均进行了HTR3A基因C178T多态性的基因分型。还研究了同一基因中的A1596G多态性。
结果
在样本1中观察到C178T基因型与气质与性格问卷中的避免伤害因子之间存在显著关联（经多重比较校正P = 0.04）；该发现随后在样本2中得到重复（P = 0.004）（合并人群：P<0.001）。在合并样本中，发现所有避免伤害子量表均与C178T多态性显著相关：预期担忧（P = 0.001）、对不确定性的恐惧（P<0.001）、害羞（P<0.001）以及易疲劳和乏力（P = 0.008）。此外，在样本1中发现C178T多态性与卡罗林斯卡人格量表中的不符合因子之间存在显著关联（校正P = 0.002），包括社会期望（P<0.001）、间接攻击（P = 0.002）、言语攻击（P = 0.05）和易怒（P<0.001）子量表。携带较罕见T等位基因（<4%）的纯合参与者在避免伤害和不符合方面的评分低于其余女性。
结论
HTR3A基因中的C178T多态性可能会影响女性的避免伤害人格特质。
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