Hexsel Doris, Serra Marcio, Mazzuco Rosemari, Dal'Forno Taciana, Zechmeister Debora
Doris Hexsel Dermatologic Clinic, Porto Alegre, Brazil.
J Drugs Dermatol. 2003 Oct;2(5):511-8.
Phosphatidylcholine was initially used in emergencies and in the treatment of atheroma plaques in cardiac diseases. Recently, it has also been used in the treatment of localized fat deposits. We report on the authors' clinical experience of the use of 250 mg/ml phosphatidylcholine injections in the treatment of subcutaneous fat deposits, showing the clinical response and side-effects. Volunteers received phosphatidylcholine injections in several areas of localized fat deposits, with a minimum interval of one week and mean interval of 15 days between applications. Laboratory tests were performed during the period of the drug use. Clinical results reflect that phosphatidylcholine was efficacious in reducing the fatty pads in the treated areas, with few side effects. From the authors' point of view, the off-label use of phosphatidylcholine in the treatment of fatty pads and small areas of localized fat is safe, low cost, and effective.
磷脂酰胆碱最初用于紧急情况以及心脏病中动脉粥样斑块的治疗。最近，它也被用于治疗局部脂肪堆积。我们报告了作者使用250毫克/毫升磷脂酰胆碱注射液治疗皮下脂肪堆积的临床经验，展示了临床反应和副作用。志愿者在几个局部脂肪堆积区域接受了磷脂酰胆碱注射，每次注射间隔至少一周，平均间隔为15天。在用药期间进行了实验室检查。临床结果表明，磷脂酰胆碱在减少治疗区域的脂肪垫方面有效，且副作用较少。从作者的角度来看，磷脂酰胆碱在治疗脂肪垫和小面积局部脂肪方面的超说明书用药是安全、低成本且有效的。
