Concept Clinic, Geneva, Switzerland.
Department of Anatomy II, Ludwig-Maximilians-University of Munich, Munich, Germany.
Clin Cosmet Investig Dermatol. 2014 May 23;7:171-83. doi: 10.2147/CCID.S59851. eCollection 2014.
Extracorporeal shock wave therapy has been successfully introduced for the treatment of cellulite in recent years. However, it is still unknown whether the individual clinical outcome of cellulite treatment with extracorporeal shock wave therapy can be predicted by the patient's individual cellulite grade at baseline, individual patient age, body mass index (BMI), weight, and/or height.
Fourteen Caucasian females with cellulite were enrolled in a prospective, single-center, randomized, open-label Phase II study. The mean (± standard error of the mean) cellulite grade at baseline was 2.5±0.09 and mean BMI was 22.8±1.17. All patients were treated with radial extracorporeal shock waves using the Swiss DolorClast(®) device (Electro Medical Systems, S.A., Nyon, Switzerland). Patients were treated unilaterally with 2 weekly treatments for 4 weeks on a randomly selected side (left or right), totaling eight treatments on the selected side. Treatment was performed at 3.5-4.0 bar, with 15,000 impulses per session applied at 15 Hz. Impulses were homogeneously distributed over the posterior thigh and buttock area (resulting in 7,500 impulses per area). Treatment success was evaluated after the last treatment and 4 weeks later by clinical examination, photographic documentation, contact thermography, and patient satisfaction questionnaires.
The mean cellulite grade improved from 2.5±0.09 at baseline to 1.57±0.18 after the last treatment (ie, mean δ-1 was 0.93 cellulite grades) and 1.68±0.16 at follow-up (ie, mean δ-2 was 0.82 cellulite grades). Compared with baseline, no patient's condition worsened, the treatment was well tolerated, and no unwanted side effects were observed. No statistically significant (ie, P<0.05) correlation was found between individual values for δ-1 and δ-2 and cellulite grade at baseline, BMI, weight, height, or age.
Radial shock wave therapy is a safe and effective treatment option for cellulite. The individual clinical outcome cannot be predicted by the patient's individual cellulite grade at baseline, BMI, weight, height, or age.
近年来，体外冲击波疗法已成功应用于治疗蜂窝组织炎。然而，目前尚不清楚个体基线时的蜂窝组织炎分级、个体患者年龄、体重指数（BMI）、体重和/或身高是否可以预测体外冲击波疗法治疗蜂窝组织炎的个体临床疗效。
本前瞻性、单中心、随机、开放标签 II 期研究共纳入 14 例白人女性蜂窝组织炎患者。基线时的平均（±标准误差）蜂窝组织炎分级为 2.5±0.09，平均 BMI 为 22.8±1.17。所有患者均采用瑞士 DolorClast®（®）设备（Electro Medical Systems，SA，Nyon，瑞士）进行径向体外冲击波治疗。患者在随机选择的一侧（左侧或右侧）每周接受 2 次治疗，共 4 周，共 8 次治疗，治疗压力为 3.5-4.0 巴，每次治疗 15 Hz 应用 15000 次脉冲。脉冲均匀分布于大腿后侧和臀部区域（每个区域产生 7500 个脉冲）。最后一次治疗后和 4 周后通过临床检查、照片记录、接触热成像和患者满意度问卷评估治疗效果。
平均蜂窝组织炎分级从基线时的 2.5±0.09 改善至最后一次治疗时的 1.57±0.18（即平均δ-1为 0.93 个蜂窝组织炎分级）和随访时的 1.68±0.16（即平均δ-2为 0.82 个蜂窝组织炎分级）。与基线相比，无患者病情恶化，治疗耐受性良好，未观察到不良副作用。个体的δ-1和δ-2值与基线时的蜂窝组织炎分级、BMI、体重、身高或年龄之间无统计学显著（即 P<0.05）相关性。
径向冲击波疗法是治疗蜂窝组织炎的一种安全有效的治疗选择。个体的临床疗效不能通过患者基线时的个体蜂窝组织炎分级、BMI、体重、身高或年龄来预测。
