Savelli Jean-Luc, Narce Michel, Fustier Véronique, Poisson Jean-Pierre
Faculté des sciences et techniques, université de Corse, Corté, France.
C R Biol. 2003 Jun;326(6):543-52. doi: 10.1016/s1631-0691(03)00145-8.
Total lipid fatty acid composition was investigated in brain hemispheres of male Spontaneously Hypertensive Rats (SHR), compared with normotensive Wistar Kyoto rats (WKY) used as controls. Both strains were suckled by adoptive Wistar mothers, and then fed a standard diet after weaning. No difference was observed between the two hemispheres of WKY killed either at 10 or 30 days. In SHR killed at 10 days, the two hemispheres showed differences, SHR left hemispheres exhibiting greater fatty acid composition changes than those of WKY, phenomenon that toned down at 30 days. Hence, SHR pups showed a different total lipid fatty acid composition of their brain hemispheres when compared with their WKY controls, though the two strains received the same diet. Genetically programmed hypertension might be, directly or not, involved in these changes.
研究了雄性自发性高血压大鼠（SHR）脑半球的总脂质脂肪酸组成，并与作为对照的正常血压Wistar Kyoto大鼠（WKY）进行了比较。两种品系均由过继的Wistar母亲哺乳，断奶后喂食标准饮食。在10天或30天时处死的WKY大鼠的两个脑半球之间未观察到差异。在10天时处死的SHR大鼠中，两个脑半球表现出差异，SHR大鼠的左脑半球脂肪酸组成变化比WKY大鼠的更大，这种现象在30天时有所减轻。因此，与WKY对照相比，SHR幼崽脑半球的总脂质脂肪酸组成不同，尽管两个品系的饮食相同。基因编程性高血压可能直接或间接参与了这些变化。
