Gattone V H
Jpn Heart J. 1986 Nov;27(6):881-4. doi: 10.1536/ihj.27.881.
The body weight of the spontaneously hypertensive rat (SHR) during the suckling, birth to 3 weeks of age, and weanling period, through 6 weeks of age, is compared to that of its normotensive controls, the Wistar Kyoto (WKY) and Wistar (WR) rats. Litters were normalized to 6 pups per dam just after birth. The WR is larger than the SHR and WKY at all time points examined. The WKY is similar in weight to the SHR at birth but larger than the SHR at the other time points studied. These findings suggest the WR is inherently a larger rat than the SHR and WKY during the suckling and weanling periods while the development of a weight difference between the SHR and WKY after birth suggest an extrauterine influence.
将自发性高血压大鼠（SHR）从出生到3周龄的哺乳期以及到6周龄的断奶期的体重，与其血压正常的对照品系，即Wistar Kyoto（WKY）大鼠和Wistar（WR）大鼠进行比较。出生后即刻将每窝幼崽数量调整为每只母鼠6只。在所有检测的时间点，WR大鼠均比SHR和WKY大鼠体型大。WKY大鼠出生时体重与SHR相似，但在其他研究时间点比SHR大。这些发现表明，在哺乳期和断奶期，WR大鼠天生就比SHR和WKY大鼠体型大，而SHR和WKY大鼠出生后体重差异的出现表明存在宫外影响。
