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[轻度颅脑损伤患者的脑血管反应性]

[Cerebrovascular reactivity in patients with mild head injury].

作者信息

Becelewski Janusz, Pierzchała Krystyna

机构信息

Kliniki Neurologii SAM w Zabrzu.

出版信息

Neurol Neurochir Pol. 2003 Mar-Apr;37(2):339-50.

PMID:14558482
Abstract

Transcranial Doppler sonography (TCD) is a non-invasive method that can be repeated to measure blood flow velocity in intracranial arteries and to assess cerebrovascular reactivity in patients with a variety of neurological diseases. The aim of this study was Doppler sonography evaluation of blood flow and reactivity in the middle cerebral artery in patients at different stages after mild head injuries. The dynamic assessment of blood flow velocity and pulsatility index both at rest and after hyperventilation in 73 patients with mild head injuries was carried out on the day of injury, the third day, sixth day and after 6 months to 5 years. The control group consisted of 61 healthy volunteers. Obtained results indicate an increase in blood flow velocity in the middle cerebral artery on the day of injury and a decrease within the following days in younger patients (aged xleq 30 yrs). Also their cerebrovascular reactivity was significantly lower. In older persons (age > 30 yrs) and in patients with remotely suffered injuries, neither blood flow velocity in the middle cerebral arteries nor cerebrovascular reactivity differed significantly from the results of the respective age control groups. The findings justify a conclusion that mild head injury is followed by changes both in the blood flow and cerebrovascular reactivity. In younger patients with mild head injuries these haemodynamic disturbances seem to be connected with altered activity of the autonomic system.

摘要

经颅多普勒超声检查(TCD)是一种非侵入性方法,可重复用于测量颅内动脉的血流速度,并评估患有各种神经系统疾病患者的脑血管反应性。本研究的目的是对轻度头部受伤后不同阶段患者的大脑中动脉血流和反应性进行多普勒超声评估。在受伤当天、第三天、第六天以及6个月至5年后,对73例轻度头部受伤患者在静息状态和过度通气后进行了血流速度和搏动指数的动态评估。对照组由61名健康志愿者组成。获得的结果表明,年轻患者(年龄≤30岁)在受伤当天大脑中动脉血流速度增加,随后几天血流速度下降。而且他们的脑血管反应性明显较低。在老年患者(年龄>30岁)和既往有过头部受伤的患者中,大脑中动脉的血流速度和脑血管反应性与相应年龄对照组的结果相比均无显著差异。这些发现证明了这样一个结论:轻度头部受伤后会伴随血流和脑血管反应性的变化。在轻度头部受伤的年轻患者中,这些血液动力学紊乱似乎与自主神经系统活动的改变有关。

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2
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