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配偶间活体非亲属供肾移植

Living unrelated donor kidney transplantation between spouses.

作者信息

Haberal M, Gulay H, Tokyay R, Oner Z, Enunlu T, Bilgin N

机构信息

Turkish Transplantation and Burn Foundation Hospital, Ankara.

出版信息

World J Surg. 1992 Nov-Dec;16(6):1183-7. doi: 10.1007/BF02067097.

DOI:10.1007/BF02067097
PMID:1455893
Abstract

From November 3, 1975 to November 3, 1990, 874 kidney transplants were performed at out centers. Of these, 675 (77.2%) were from living donors and 199 (22.8%) were from cadaver donors. Five hundred eighty (66.4%) of the living donors were first degree related while 99 (11.3%) were unrelated or second degree related donors, 29 of which were spouses. All donor recipient pairs were ABO-compatible, with the exception of one pair. Donor recipient relations were wife to husband in 25 cases and husband to wife in 4 cases. All were first grafts and started functioning during surgery. In this series, the follow-up for the recipients was 4 to 64 months (mean 33.5 +/- 4.5 months). One-year patient survival and graft survival rates were 92.4% and 81.9%, respectively. Two-year patient survival and graft survival rates were 92.4% and 78.2%, respectively. The single ABO-incompatible case is also doing well, 21 months postoperatively. This study demonstrates that the interspouse kidney transplantation may be used when cadaver organ shortage is a problem. While providing the couple with a better quality of life, interspouse kidney transplantation also enables the couple to share the joy of giving and receiving the "gift of life" from one another.

摘要

1975年11月3日至1990年11月3日期间,我们中心共进行了874例肾移植手术。其中,675例(77.2%)来自活体供体,199例(22.8%)来自尸体供体。580例(66.4%)活体供体为一级亲属,99例(11.3%)为非亲属或二级亲属供体,其中29例为配偶。除1对不匹配外,所有供受者血型均相容。供受者关系为妻子供肾给丈夫的有25例,丈夫供肾给妻子的有4例。所有移植均为首次移植,且在手术中即开始发挥功能。在这一系列病例中,受者的随访时间为4至64个月(平均33.5±4.5个月)。1年的患者生存率和移植肾生存率分别为92.4%和81.9%。2年的患者生存率和移植肾生存率分别为92.4%和78.2%。唯一的1例ABO血型不匹配病例术后21个月情况也良好。本研究表明,在尸体器官短缺的情况下,夫妻间肾移植是可行的。夫妻间肾移植不仅能提高夫妻双方的生活质量,还能让他们共同分享给予和接受“生命礼物”的喜悦。

相似文献

1
Living unrelated donor kidney transplantation between spouses.配偶间活体非亲属供肾移植
World J Surg. 1992 Nov-Dec;16(6):1183-7. doi: 10.1007/BF02067097.
2
Results of kidney transplantation between spouses: a single-center experience.配偶间肾移植的结果:单中心经验
Transplant Proc. 2007 May;39(4):898-900. doi: 10.1016/j.transproceed.2007.02.051.
3
The UNOS renal transplant registry.美国器官共享联合网络肾脏移植登记处。
Clin Transpl. 2001:1-18.
4
Living kidney transplantation between spouses: results in 100 cases.
Transpl Int. 1994;7 Suppl 1:S314-7. doi: 10.1111/j.1432-2277.1994.tb01378.x.
5
High survival rates of kidney transplants from spousal and living unrelated donors.来自配偶及活体非亲属供体的肾移植存活率高。
N Engl J Med. 1995 Aug 10;333(6):333-6. doi: 10.1056/NEJM199508103330601.
6
Living unrelated kidney transplantation.活体非亲属肾移植
World J Surg. 2002 Feb;26(2):238-42. doi: 10.1007/s00268-001-0211-4. Epub 2001 Dec 21.
7
Renal transplantation at the University of Pennsylvania Medical Center: an update of results in the cyclosporine era.宾夕法尼亚大学医学中心的肾移植:环孢素时代的结果更新
Clin Transpl. 1992:215-25.
8
The UNOS Scientific Renal Transplant Registry.美国器官共享联合网络科学肾脏移植登记处。
Clin Transpl. 1999:1-21.
9
Annual trends and triple therapy--1991-2000.1991 - 2000年的年度趋势与三联疗法
Clin Transpl. 2001:247-69.
10
The OPTN/UNOS Renal Transplant Registry.器官获取与移植网络/美国器官共享联合网络肾脏移植登记处
Clin Transpl. 2005:1-16.

本文引用的文献

1
Successful renal transplantation using distantly related or unrelated living donors with donor-specific blood transfusion.使用远亲或无关活体供体并进行供体特异性输血的成功肾移植。
Transplantation. 1985 Apr;39(4):450-3.
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The living donor in kidney transplantation.肾移植中的活体供体。
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Transplantation in Kuwait--a middle eastern and North African perspective.科威特的移植——中东和北非视角
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Living donor kidney transplantation.活体供肾移植
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Use of the donor specific transfusion protocol in living-unrelated donor-recipient combinations.在非亲属活体供者-受者组合中使用供者特异性输血方案。
Ann Surg. 1986 Sep;204(3):315-21. doi: 10.1097/00000658-198609000-00010.
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Kidney transplantation from unrelated living donors. Time to reclaim a discarded opportunity.
N Engl J Med. 1986 Apr 3;314(14):914-6. doi: 10.1056/NEJM198604033141409.
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Living donor kidney transplantation.活体供肾肾移植
Transplant Proc. 1988 Feb;20(1 Suppl 1):353-5.
8
Organ supply--whither growth?器官供应——何去何从?
Am J Kidney Dis. 1988 Dec;12(6):552-4. doi: 10.1016/s0272-6386(88)80111-2.
9
Living-unrelated renal transplantation: results in 40 patients.活体非亲属肾移植:40例患者的结果
Am J Kidney Dis. 1988 Dec;12(6):499-503. doi: 10.1016/s0272-6386(88)80101-x.
10
The use of HLA-mismatched living related donors for renal transplantation is justified by the highly successful long-term results.使用HLA不匹配的活体亲属供体进行肾移植,因其长期效果非常成功而具有合理性。
Transplant Proc. 1988 Oct;20(5):800-1.