Sollinger H W, Kalayoglu M, Belzer F O
Ann Surg. 1986 Sep;204(3):315-21. doi: 10.1097/00000658-198609000-00010.
The scarcity of suitable cadaver or living-related kidneys remains the major problem in renal transplantation. The use of the donor-specific transfusion protocol (DST) has allowed for the expansion of the donor pool to one- and two-haplotype mismatched living-related donor-recipient combinations. This study deals with the use of DST in living-unrelated donor-recipient combinations (LURD). The following 34 LURD combinations were entered: husband to wife; wife to husband; friend to friend; stepfather; brother-in-law and sister-in-law. Donor-specific sensitization occurred in 21%. Actuarial graft survival at 4 years is 92.6%, and patient survival is 100%. It is concluded that this study indicates that the results with the use of LURDs equal the results with living-related donors and, therefore, it is suggested that the use of LURDs can be considered in situations when a medically and ethically acceptable unrelated donor is available.
合适的尸体供肾或亲属活体供肾的稀缺仍然是肾移植中的主要问题。供者特异性输血方案（DST）的应用使得供者库扩大到了单倍型和双倍型错配的亲属活体供者 - 受者组合。本研究探讨了DST在非亲属活体供者 - 受者组合（LURD）中的应用。纳入了以下34例LURD组合：丈夫供妻子；妻子供丈夫；朋友供朋友；继父；姐夫/妹夫供小姨子/小舅子。供者特异性致敏发生率为21%。4年时移植肾的预期生存率为92.6%，患者生存率为100%。研究得出结论，本研究表明使用LURD的结果与亲属活体供者的结果相当，因此建议在有医学和伦理上可接受的非亲属供者时，可以考虑使用LURD。
