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[将脑神经元移植到脊髓中治疗截瘫]

[Transplantation of cerebral neurons into spinal cord for the treatment of paraplegia].

作者信息

Vaquero Crespo Jesús

出版信息

An R Acad Nac Med (Madr). 2003;120(1):47-61; discussion 62-3.

Abstract

This report shows the experimental results obtained after microsurgical cotransplantation of fetal cerebral tissue and peripheral nerve tissue into previously injured spinal cord. Between 8 and 12 months after surgery, functional recovery is observed in the grafted animals, associated with an increase in muscle mass in the lower extremities. At this time, donor cerebral tissue is integrated into previously injured spinal cord and results in formation of bundles of nerve fibers that emerge from the area of the transplant and surround the spinal cord beneath the lesion. These findings support the possibility of functional recovery after chronic traumatic paraplegia.

摘要

本报告展示了将胎儿脑组织和周围神经组织显微外科联合移植到先前受损脊髓后所获得的实验结果。术后8至12个月,在移植的动物身上观察到功能恢复,同时伴有下肢肌肉量增加。此时,供体脑组织融入先前受损的脊髓,并导致形成从移植区域发出并环绕病变下方脊髓的神经纤维束。这些发现支持了慢性创伤性截瘫后功能恢复的可能性。

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